DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fzd1 and fz

DIOPT Version :10

Sequence 1:NP_067432.2 Gene:Fzd1 / 14362 MGIID:1196625 Length:642 Species:Mus musculus
Sequence 2:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster


Alignment Length:584 Identity:276/584 - (47%)
Similarity:355/584 - (60%) Gaps:66/584 - (11%)


- Green bases have known domain annotations that are detailed below.


Mouse    78 SGPGQQAPPPPQPQQSGQQYNGERGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAG 142
            ||.|..|       .||.:.:|     :|.|..|:||:|.:|.:|.||.||||||:|||.||:||
  Fly    32 SGGGLMA-------SSGTELDG-----LPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAG 84

Mouse   143 LEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDT 207
            ||||||.||||:.||.:|:.||||:|.||||:||:.:||||||||.||. ||.||..:.|.||:.
  Fly    85 LEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESARV-CEKLMKTYNFNWPEN 148

Mouse   208 LKCEKFPVHGAGELCVGQNT----SDKGTPTPSLLP------EFWTSNPQHGGGGYRGGYPGGAG 262
            |:|.||||||..:|||.:||    |...|||.|:..      :....:|....|           
  Fly   149 LECSKFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIG----------- 202

Mouse   263 TVERGKFSCPRALRVPSYLNYHF-LGEK---DCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSV 323
                  |.||..|:.|..:.|.. :|.|   ||||||.      .|:|...|....|.|:|.|:.
  Fly   203 ------FVCPVQLKTPLGMGYELKVGGKDLHDCGAPCH------AMFFPERERTVLRYWVGSWAA 255

Mouse   324 LCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAE------ 382
            :|.||.||||||:|:|..||.||||.|:||:.||..|..||:||....|.|.|.:.|..      
  Fly   256 VCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGR 320

Mouse   383 -DGARTVAQGTKK-EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLA 445
             ....|:.||.:: ..||:|||.|||..||:..||..|:..||||||:||||||||..|..|||.
  Fly   321 LQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLV 385

Mouse   446 AWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFR 510
            ||||||::||::|||.:|:||:||||||||..:..:|..|::.||.:||.||..||||||:||||
  Fly   386 AWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFR 450

Mouse   511 IRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIP 575
            |||:||.||.:|:|||:||:|||.||.|:.:||..::.|.|||....|:|...|....||.::||
  Fly   451 IRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIP 515

Mouse   576 CPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGE 639
            ||    ....|..|...|.|.:||:|||.:::||:||..|::|.||:.|||.|..||    ||:
  Fly   516 CP----AARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERL----QGK 571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fzd1NP_067432.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..45
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 76..99 6/20 (30%)
CRD_FZ1 107..233 CDD:143574 77/129 (60%)
7tmF_FZD1 294..641 CDD:320375 173/354 (49%)
TM helix 1 313..338 CDD:320375 13/24 (54%)
TM helix 2 347..368 CDD:320375 11/20 (55%)
TM helix 3 398..424 CDD:320375 13/25 (52%)
TM helix 4 441..457 CDD:320375 11/15 (73%)
TM helix 5 479..508 CDD:320375 14/28 (50%)
TM helix 6 528..555 CDD:320375 14/26 (54%)
TM helix 7 591..616 CDD:320375 11/24 (46%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 620..625 2/4 (50%)
PDZ-binding 640..642 276/584 (47%)
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 73/116 (63%)
7tmF_FZD1_insect 236..568 CDD:320376 167/335 (50%)
TM helix 1 245..270 CDD:320376 13/24 (54%)
TM helix 2 279..300 CDD:320376 11/20 (55%)
TM helix 3 338..364 CDD:320376 13/25 (52%)
TM helix 4 381..397 CDD:320376 11/15 (73%)
TM helix 5 419..448 CDD:320376 14/28 (50%)
TM helix 6 468..495 CDD:320376 14/26 (54%)
TM helix 7 527..552 CDD:320376 11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

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