DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fzd1 and fz2

DIOPT Version :9

Sequence 1:NP_067432.2 Gene:Fzd1 / 14362 MGIID:1196625 Length:642 Species:Mus musculus
Sequence 2:NP_001262037.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:806 Species:Drosophila melanogaster


Alignment Length:658 Identity:279/658 - (42%)
Similarity:362/658 - (55%) Gaps:127/658 - (19%)


- Green bases have known domain annotations that are detailed below.


Mouse    53 GLLLLLWLLEA--PLLLGVRAQAAGQVSGPGQQAPPPPQPQQSGQQYNGERGISIP-----DHGY 110
            ||:|||....|  ||...........:.|.|..|.|.|             |..:|     .:..
  Fly    12 GLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAP-------------GYGVPVIPKDPNLR 63

Mouse   111 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVL 175
            |:.|:||:|..|.||.|..||.:.|..|::||||||||:|||:::||.:|||||||||.|:|  |
  Fly    64 CEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC--L 126

Mouse   176 E---QALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHG-AGELCV------------- 223
            |   :.||.|||:|||||.||..:|.::.|:||:.:.||..|:|| ...||:             
  Fly   127 EDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGS 191

Mouse   224 --GQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGTVE----RGKFS------------ 270
              |...|..|:.:..       ...|.|.|....|..|.:|:..    ||:.|            
  Fly   192 SGGSGGSGSGSGSGG-------KRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKAS 249

Mouse   271 ---CPRALRVPS------------------------YLN---YHFLGEKDCGAPCEPTKVYGLMY 305
               |..:.|.|.                        |:|   ....|..:||.||:..      :
  Fly   250 GKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGP------F 308

Mouse   306 FGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIA-GFL 369
            |..:|..|:..||.:||.||..|||.|:.|:::|..||.||||||:|||.||..|||.|:: .||
  Fly   309 FSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFL 373

Mouse   370 LEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEA 434
            ..:.:.|      ||.......|....||::|::.|||.|||||||||||.|||||||:|||:||
  Fly   374 QNEEIAC------DGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEA 432

Mouse   435 IEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTS 499
            |..:|||||||||.:|.::::.:|.|..||||.:.|:|:||..|.|.|:.||||||||||.|||:
  Fly   433 ITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTT 497

Mouse   500 FLLAGFVSLFRIRTIMKHD-----GTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQ 559
            ||:||||||||||:::|..     |.|.:||||||:|||:|||||||||||||.||.||.|:.:.
  Fly   498 FLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFED 562

Mouse   560 WERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNS 624
            |        .|:.|.||..::|       |...|.::|.|:||.|.|.||||||.||||||||.|
  Fly   563 W--------IKALACPCAQVKG-------PGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLES 612

Mouse   625 WRKFYTRL 632
            ||:|:.||
  Fly   613 WRRFWRRL 620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fzd1NP_067432.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..45
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 76..99 5/22 (23%)
CRD_FZ1 107..233 CDD:143574 65/144 (45%)
7tmF_FZD1 294..641 CDD:320375 182/345 (53%)
TM helix 1 313..338 CDD:320375 12/24 (50%)
TM helix 2 347..368 CDD:320375 13/21 (62%)
TM helix 3 398..424 CDD:320375 18/25 (72%)
TM helix 4 441..457 CDD:320375 8/15 (53%)
TM helix 5 479..508 CDD:320375 21/28 (75%)
TM helix 6 528..555 CDD:320375 22/26 (85%)
TM helix 7 591..616 CDD:320375 13/24 (54%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 620..625 3/4 (75%)
PDZ-binding 640..642
fz2NP_001262037.1 CRD_FZ5_like 63..182 CDD:143565 62/120 (52%)
Frizzled 308..618 CDD:279827 178/330 (54%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X126
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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