DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fzd1 and Corin

DIOPT Version :9

Sequence 1:NP_067432.2 Gene:Fzd1 / 14362 MGIID:1196625 Length:642 Species:Mus musculus
Sequence 2:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster


Alignment Length:211 Identity:56/211 - (26%)
Similarity:83/211 - (39%) Gaps:48/211 - (22%)


- Green bases have known domain annotations that are detailed below.


Mouse   106 PDHGYCQPISIPLC--TDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMY 168
            |..|.|.||.:..|  ..|.||.|:.||.:||..|.:...::..:..||.|:|...:..|||:::
  Fly   774 PAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLF 838

Mouse   169 APVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTP 233
            .|.|......:|||::||....:.|....:.||...|:.|.|:.|....:.|.|||         
  Fly   839 VPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVG--------- 894

Mouse   234 TPSLLPEF-----WTSNPQHGGGGYRGGYPGGAGTVERGKFSCPRALRVPSYLNYHFLGEKDC-- 291
                |.|.     ..::|:..|                  |.|.:...:|.  .|...|..||  
  Fly   895 ----LDEVREVMRAATHPKCDG------------------FQCDQNRCLPQ--EYVCDGHLDCMD 935

Mouse   292 ---GAPCE---PTKVY 301
               .|.||   |.::|
  Fly   936 QADEAKCERCGPDEIY 951

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fzd1NP_067432.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..45
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 76..99
CRD_FZ1 107..233 CDD:143574 39/127 (31%)
7tmF_FZD1 294..641 CDD:320375 4/11 (36%)
TM helix 1 313..338 CDD:320375
TM helix 2 347..368 CDD:320375
TM helix 3 398..424 CDD:320375
TM helix 4 441..457 CDD:320375
TM helix 5 479..508 CDD:320375
TM helix 6 528..555 CDD:320375
TM helix 7 591..616 CDD:320375
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 620..625
PDZ-binding 640..642
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 36/115 (31%)
LDLa 911..942 CDD:238060 9/50 (18%)
LDLa 945..979 CDD:238060 2/7 (29%)
SR 980..>1034 CDD:214555
SRCR 992..1086 CDD:278931
Tryp_SPc 1103..1343 CDD:214473
Tryp_SPc 1104..1346 CDD:238113
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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