DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CSF1R and Cad96Ca

DIOPT Version :9

Sequence 1:NP_001275634.1 Gene:CSF1R / 1436 HGNCID:2433 Length:972 Species:Homo sapiens
Sequence 2:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster


Alignment Length:798 Identity:206/798 - (25%)
Similarity:304/798 - (38%) Gaps:270/798 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   247 PQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQ 311
            |::..|..:|...|:|||                .::.|:                  :.||.:.
  Fly   109 PEKIPFQIDRETGVVTLN----------------ESLAGR------------------AGQNFLI 139

Human   312 EVTVGEGLNLKVMVEAYPGLQGFNWTYLGP---FSDHQPEPKLANATTKDTYRHTFTLSLPR--- 370
            .:||.:|        :|..........||.   .|.::|:..::|..      |..:..|||   
  Fly   140 YITVTDG--------SYTAKNEVFINILGERENSSGYRPQTSISNVV------HNISQFLPRFDQ 190

Human   371 LKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGY--PQPNVTWL- 432
            |...::.|.......||||          |||   |....|.|....   .:.|  |.||:..: 
  Fly   191 LPGVQSIRNGLPNSRPGGW----------YPP---VPQNNIFGPPPF---GNNYPPPPPNIPGVR 239

Human   433 -QCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFH----------KVT---------VQSLLTVETL 477
             :.||..::.||            ||....|..          |:|         |:|.:..|| 
  Fly   240 GEQSGEEEQPDE------------EVTPTTPVRISSTTPKSRTKLTPITANNSTRVESAIPAET- 291

Human   478 EHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLL------ 536
                |.....|::..|.......:.:|.          .|:||........:.:||..|      
  Fly   292 ----TTPSGGHHNNSSSPITIFSLKSGT----------IPIVVTVGGFFVAIAVLLAYLCRRRLC 342

Human   537 -----LYKYKQKPKYQVRWK----------------IIESYEG-----NSYT--------FIDPT 567
                 |.|.|:|.:...:..                :::.::|     |.|.        .|..:
  Fly   343 AISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATS 407

Human   568 QL----------------------------------------PYN--------EKWEFPRNNLQF 584
            ||                                        |.|        ::|||||..|:|
  Fly   408 QLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKF 472

Human   585 GKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNL 649
            ...||.||||:|....|..:...:.:..||||.||.:|...:::.|:|||::|..|..|.|:|:|
  Fly   473 FNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHL 537

Human   650 LGACTHGGPVLVITEYCCYGDLLNFLR-RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDS 713
            ||.||...|..||.||...|.|..:|| .:||.                .|.|.|          
  Fly   538 LGCCTDKDPTFVILEYVNRGKLQTYLRSSRAER----------------HYGNTH---------- 576

Human   714 GFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRD 778
            |.|:           |.||.                    ||..|..|||:||.:|.|:..||||
  Fly   577 GKSN-----------VLTSC--------------------DLTSFMYQVAKGMDYLTSRGIIHRD 610

Human   779 VAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGI 843
            :||||:|:|:.|..|:.|||.|||::....|..|...:||::|||.||::|.:::|:||:||:||
  Fly   611 LAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGI 675

Human   844 LLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICS 908
            |:|||.:||..|||||.......| |:|||::.:|....:.:|:||..||:.:|..||.|.:|..
  Fly   676 LMWEIVTLGSTPYPGISAADVMRK-VRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQ 739

Human   909 FLQEQAQEDRRERDYTNL 926
            .|.:..   ..|.||..|
  Fly   740 MLDKLL---HTEMDYIEL 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CSF1RNP_001275634.1 IG_like 28..85 CDD:214653
ig 207..293 CDD:365836 8/45 (18%)
Ig4_SCFR_like 299..400 CDD:319281 21/106 (20%)
Ig 416..495 CDD:319273 20/101 (20%)
Regulatory juxtamembrane domain 542..574 9/108 (8%)
PTKc_CSF-1R 543..914 CDD:133237 137/448 (31%)
Activation loop 796..818 8/21 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..950 4/9 (44%)
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637 16/96 (17%)
STYKc 470..741 CDD:214568 122/328 (37%)
PTKc 474..742 CDD:270623 120/325 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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