DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSF1R and drpr

DIOPT Version :9

Sequence 1:	NP_001275634.1	Gene:	CSF1R / 1436	HGNCID:	2433	Length:	972	Species:	Homo sapiens
Sequence 2:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster

Alignment Length:	69	Identity:	20/69 - (28%)
Similarity:	25/69 - (36%)	Gaps:	28/69 - (40%)

- Green bases have known domain annotations that are detailed below.

Human   388 GW------RALTFELTLRYPPEVSVIWTFING------SGTLLCAASGYPQPNVTWLQCSGHTDR 440
            ||      |..||   |||.|...:.....||      :||.|| |.|:..|.
  Fly   383 GWSSAQCTRPCTF---LRYGPNCELTCNCKNGAKCSPVNGTCLC-APGWRGPT------------ 431

Human   441 CDEA 444
            |:|:
  Fly   432 CEES 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSF1R	NP_001275634.1	IG_like	28..85	CDD:214653
		ig	207..293	CDD:365836
		Ig4_SCFR_like	299..400	CDD:319281	6/17 (35%)
		Ig	416..495	CDD:319273	8/29 (28%)
		Regulatory juxtamembrane domain	542..574
		PTKc_CSF-1R	543..914	CDD:133237
		Activation loop	796..818
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..950
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900