DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd2 and fs(1)h

DIOPT Version :9

Sequence 1:	NP_001191902.1	Gene:	Brd2 / 14312	MGIID:	99495	Length:	798	Species:	Mus musculus
Sequence 2:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster

Alignment Length:	1159	Identity:	427/1159 - (36%)
Similarity:	520/1159 - (44%)	Gaps:	465/1159 - (40%)

- Green bases have known domain annotations that are detailed below.

Mouse    48 ASVPALQLAPANPP------PPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK 106
            :|.|..:..|...|      ||.:...::|||.|||||||.|.|||.:|||.|:|||:|||||.|
  Fly     3 SSEPPPRYEPPVEPVNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKK 67

Mouse   107 LGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKI 171
            |.||||||||||||||||||:||||||||:|.|.:|||||||.|||:||||.:|:|:|||||||:
  Fly    68 LNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKV 132

Mouse   172 FLQKVASMPQEEQELVVTIPKNSHKK--------------GAK---------------------- 200
            ||||:.|||:||.||.....|...||              ||.
  Fly   133 FLQKIESMPKEELELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVS 197

Mouse   201 -----------------------------------------LAALQGSITS----AHQVPAVSSV 220
                                                     ::|:.|:::|    |..:|.:|::
  Fly   198 VAASSAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTM 262

Mouse   221 SHTALYTPPPEIP------TTVL--NIPHPSVI-----SSPLLKSLHSAGP-------------- 258
                   ||..:|      ||.:  .:..|...     ::.|:.||.:||.
  Fly   263 -------PPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVN 320

Mouse   259 ---------------------------------------PLLAVSAA------------------ 266
                                                   |.:||:||
  Fly   321 SSSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAV 385

Mouse   267 -PPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDL 330
             ||.||...||||||||||||||..|.      .||...::.|:|:: ..||||.|.:
  Fly   386 IPPQQPAKIKKGVKRKADTTTPTANAF------ESPYTQMDSKSAKI-ATRRESNRQV------- 436

Mouse   331 PDSQQQHQSSKKG----------------------------------KLSEQLKHCNGILKELLS 361
                    ..|||                                  |||:.||.||.|||||.|
  Fly   437 --------IGKKGSGYNMSPLGVSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFS 493

Mouse   362 KKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYK 426
            |||:.|||||||||||..|||||||||||.||||.||||||:||:|:.|.||||||||:|:||||
  Fly   494 KKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYK 558

Mouse   427 YNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAL----------------------- 468
            |||||||||||.||||||||.|||.:|||       ||:.|.
  Fly   559 YNPPDHDVVAMGRKLQDVFEMRYANIPDE-------PVANAAHHHGHGHGHGHGHGHGHGHGHGH 616

Mouse   469 --PPGLTKSSS-ESSSEESSSESSSEEEEEEEEDEDEEESESSDSEEERAHRLAELQEQLRAVHE 530
              ..|...||| :..:.:||||.||:.|.|            |:|:|||:.||..|:.:|..:.|
  Fly   617 GHGHGYGGSSSLKHDASDSSSEDSSDTENE------------SNSDEERSARLKMLESKLLGLQE 669

Mouse   531 QLAALSQGPISKPKRKREKKEKKK-------KRKAEKHRGRIGIDEDDKGPRAP----------- 577
            ::..||:...:|.|.|::.|||||       ...|..|....|...:..|...|
  Fly   670 EIRKLSEEASAKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGHGSVSVP 734

Mouse   578 ----------------------------------------------RPPQPKKSKKAGGG----- 591
                                                          .......|:.||||
  Fly   735 GGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMAGGGAAAGA 799

Mouse   592 -------------GSNATTLSHP------------------------------------GFGTS- 606
                         |..|.||:..                                    |.|.|
  Fly   800 GFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSGAGGVGASN 864

Mouse   607 -------------------------------GGSSNKLPKKSQKTA------------------- 621
                                           ||:::|..|.|....
  Fly   865 NAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANASAGGAGARG 929

Mouse   622 ----PPVLPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEI 682
                .|.....:|||||:.::|||||||||||||||||||:||||||||||.||||||||||:||
  Fly   930 SSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEI 994

Mouse   683 EIDFETLKPSTLRELERYVLSCLRKKPRKPYTIRKPVGKTKEELALEKKRELEKRLQDVSGQLNS 747
            ||||||||||||||||.||.||||||     |.:||.||:|:|...|||:|||||||||:|||.:
  Fly   995 EIDFETLKPSTLRELESYVASCLRKK-----THKKPSGKSKDEQMAEKKQELEKRLQDVTGQLGA 1054

Mouse   748 TKKPPKK---ASEKTESSAQQVAVSRLSASSSSSDSSSSSSS-SSSSDTSDSDS 797
            :||..||   ||.|.|  |.|.| :.:|:||||||||||||| |||||:|||::
  Fly  1055 SKKTAKKDESASSKVE--AVQPA-NPVSSSSSSSDSSSSSSSDSSSSDSSDSEA 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd2	NP_001191902.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72		4/24 (17%)
		Bromo_Brdt_I_like	73..179	CDD:99929	81/105 (77%)
		PHA03247	<215..332	CDD:223021	46/201 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		34/114 (30%)
		Bromo_Brdt_II_like	348..449	CDD:99930	81/100 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..645		70/389 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	553..557		2/10 (20%)
		BET	639..701	CDD:407211	57/61 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..798		42/66 (64%)
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	81/105 (77%)
		COG5076	387..>593	CDD:227408	123/234 (53%)
		Bromo_Brdt_II_like	481..581	CDD:99930	81/99 (82%)
		BET	951..1015	CDD:293640	59/63 (94%)
		BRD4_CDT	<2026..2046	CDD:293710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4071
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	1	1.000	-	-		otm43131
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	LDO	PTHR22880
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3378
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.800