DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Brd2 and tbrd-3

DIOPT Version :9

Sequence 1:	NP_001191902.1	Gene:	Brd2 / 14312	MGIID:	99495	Length:	798	Species:	Mus musculus
Sequence 2:	NP_726307.1	Gene:	tbrd-3 / 246604	FlyBaseID:	FBgn0050417	Length:	268	Species:	Drosophila melanogaster

Alignment Length:	378	Identity:	101/378 - (26%)
Similarity:	145/378 - (38%)	Gaps:	124/378 - (32%)

- Green bases have known domain annotations that are detailed below.

Mouse   346 SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDA 410
            |.::..|..|:|.|.|..:...||.||:|:|...|||||||:|::.|||||||:.::....|..|
  Fly    11 SPEINACKVIIKRLFSSTYKNIAWVFYEPLDPQLLGLHDYHEIVREPMDLSTVRHRLNTGCYLSA 75

Mouse   411 QEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTALPPGLTKS 475
            .:||.|:||:|.|.|.|..|||....||::||.:||..|::                :...:..|
  Fly    76 ADFAKDIRLIFYNTYLYTNPDHLCYHMAKQLQIIFEEMYSQ----------------VQLYICSS 124

Mouse   476 SSESSSEESSSESSSEEEEEEEEDEDEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPI 540
            .|:..:||   ||||:|.:....:::...||.|.|                       .:...|.
  Fly   125 GSKVRAEE---ESSSDESDSSSPEDEVNGSEVSPS-----------------------IMGAPPS 163

Mouse   541 SKPKRKREKKEKKKKRKAEKHRGRIGIDEDDKGPRAPRPPQPKKSKKAGGGGSNATTLSHPGFGT 605
            ..|                                                    ||...|
  Fly   164 CTP----------------------------------------------------TTECTP---- 172

Mouse   606 SGGSSNKLPKKSQKTAPPVLPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAR 670
                      ....|.|..|.|   ||::|   |.:.:|...|...|.:|.||.|..|:|.||..
  Fly   173 ----------TPDWTPPATLET---SEQQE---PFTTEEDLDLHAKIQQLDGEVLLHVIHFIQRM 221

Mouse   671 EPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIRKPVGKTK 723
            |.:  :...:|:|.|...||..|.|.:..|:.|       |.:| .|.|.:||
  Fly   222 EGA--EYCNKELEFDICKLKVHTKRGIRDYLAS-------KGFT-GKRVARTK 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd2	NP_001191902.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72
		Bromo_Brdt_I_like	73..179	CDD:99929
		PHA03247	<215..332	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		1/1 (100%)
		Bromo_Brdt_II_like	348..449	CDD:99930	46/100 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..645		26/190 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	553..557		0/3 (0%)
		BET	639..701	CDD:407211	20/61 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..798
tbrd-3	NP_726307.1	Bromo_Brdt_II_like	13..114	CDD:99930	46/100 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910