Protein Alignment MPP7 and metro

DIOPT Version :9

• Sequence 1: XP_016871230.1
• Gene: MPP7 / 143098
• HGNCID: 26542
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 235/598 - (39%)
• Similarity: 356/598 - (59%)
• Gaps: 50/598 - (8%)

Human    95 LNWN---SLWLSEGRVSGERWADLFLHLASCQLCQRDLGVTL-IHEKLHYYEKQSPV-PILHGAA 154
            :||:   |..:|..:.|.....|..:......|..::|...: :|.|:....:...: |:|..:|
  Fly    10 INWDPALSKLISTLKESENLSNDQEIDFLKALLESKELNALVNVHTKVAKVGRDDRLAPVLSTSA 74

Human   155 ALADDLAEEL-QNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSV 218
            .:..::.|:| |:..||.:.:|...||...:::.||..||.:|||::.|.||..|.::|::|:::
  Fly    75 QVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETI 139

Human   219 KIIRLVKNREPL----------GATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIP 273
            ||::|||:.|||          |||||.||::|.||:||||.|||||||||||||||:.|||.|.
  Fly   140 KIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNIN 204

Human   274 VEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFK 338
            ||.|.|.:::.||..|:|.||||::|...:.. .:|.|:.::|.|||||:.|..||||||||:|:
  Fly   205 VEGKTPGDVLTILQNSEGTITFKLVPADNKGA-QRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQ 268

Human   339 KGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLALRRPE---------------ILV 388
            :||:|.|::||||.||||:.|.:.:.|||||||:..||||:...|.:               :..
  Fly   269 RGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCT 333

Human   389 QP-----LKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTP-YRRQTNE 447
            .|     |..|:..|         |.:..||.|.||:..::|.:|...:.|||||.. |.|.  .
  Fly   334 TPPGSPRLPASSSTS---------SCRQPKTKKIMYDLTENDDFDREQIATYEEVAKLYPRP--G 387

Human   448 KYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQN 512
            .:|.:||:|..|||.|||:|:|:..|.:.:...||:|||..|:.|..|.||||:::...:.|::.
  Fly   388 VFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEA 452

Human   513 NKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRE 577
            .||:|:||||.:.||||.:||:|::....||:|......:|.|||.:.||::|.:|||.::.|:.
  Fly   453 GKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKA 517

Human   578 TRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDK 642
            ||..|: ..|..|:..|:.||:|:|::|||||:.::..|||.||..::|.:|..||.:|.....:
  Fly   518 TRTEAR-AKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQR 581

Human   643 LETETHWVPVSWL 655
            ||.|..|.|..|:
  Fly   582 LENEPVWAPSMWV 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MPP7	XP_016871230.1	None
metro	NP_610642.2	L27	17..68	CDD:197794	8/50 (16%)
		L27	75..127	CDD:197794	17/51 (33%)
		PDZ_signaling	139..229	CDD:238492	53/89 (60%)
		SH3_MPP	243..302	CDD:212796	35/58 (60%)
		Guanylate_kin	390..575	CDD:279019	78/185 (42%)
		GuKc	399..580	CDD:214504	75/181 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158378
Domainoid	1	1.000	92	1.000	Domainoid score	I7619
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1455
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1731
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49437
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	1	1.000	-	-		otm41189
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23122
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5259
SonicParanoid	1	1.000	-	-		X2258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	14.000