DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fosl2 and kay

DIOPT Version :9

Sequence 1:	NP_032063.2	Gene:	Fosl2 / 14284	MGIID:	102858	Length:	326	Species:	Mus musculus
Sequence 2:	NP_001027577.2	Gene:	kay / 3772082	FlyBaseID:	FBgn0001297	Length:	755	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	96/396 - (24%)
Similarity:	147/396 - (37%)	Gaps:	136/396 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 YQDYPGNFDTSSRGSSGSPAHAESYSSG--------GGGQQKF----RVDMPGSGSAFIPTINAI 54
            |.|...|.:..:..:|.:...:.||.:|        |||...|    .......|||.:.:.||.
  Fly   329 YNDTQMNEEQDTTDTSSAHTDSTSYQAGHIMAGSVNGGGVNNFSNVLAAVSSSRGSASVGSSNAN 393

Mouse    55 TTSQDLQWMVQPTVITSMSNPYPRSHPYSPLPGLASVPGHMALPRPGVIKTIGTTVGRR-RRDEQ 118
            |                 ||...|                    |.|         ||| .|...
  Fly   394 T-----------------SNTPAR--------------------RGG---------GRRPNRSTN 412

Mouse   119 LSPEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELEEEKSGLQKEIAELQKEKEKLEFM 183
            ::||||:||.:||||||.|||:||.||.:.|.:|..|.|:||:....::|||..|...|.:||::
  Fly   413 MTPEEEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVLTNSKNQLEYL 477

Mouse   184 LVAHGPVCK---------------ISPEERRSPPTSGL----------------------QSLRG 211
            |..|...|:               |:|....|..:||.                      .:|..
  Fly   478 LATHRATCQKIRSDMLSVVTCNGLIAPAGLLSAGSSGSGASSHHNHNSNDSSNGTITGMDATLNS 542

Mouse   212 TGSAVGPVVVK------------QEPPEEDSPSSSAGMDK-----TQRSVIKPISIAGGGFYGEE 259
            ||.:..|:.:|            ::.|.:.:..|.:.:|:     ::|..:.|:|..       .
  Fly   543 TGRSNSPLDLKPAANIDSLLMHIKDEPLDGAIDSGSSLDQDGPPPSKRITLPPMSTM-------P 600

Mouse   260 PLHTPIVVTSTPAI-----TPGTSNLVFTYPNVLEQESPSSPSESCSKAHRRSSSSGDQSSDSLN 319
            .:|...::|.|.|.     ||.||    |.|.......|.:.:.|       |.::.:...:::|
  Fly   601 HVHLSTILTPTGASSGSLQTPITS----TAPGGFGSAFPVTSNGS-------SINNINSIGNNMN 654

Mouse   320 SPTLLA 325
            ||||.|
  Fly   655 SPTLNA 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fosl2	NP_032063.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		11/48 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..131		10/21 (48%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	126..128		1/1 (100%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	129..136		5/6 (83%)
		bZIP_Fos	134..187	CDD:269869	23/52 (44%)
		coiled coil	134..186	CDD:269869	23/51 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..244		14/89 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..326		10/41 (24%)
kay	NP_001027577.2	bZIP_Fos	420..481	CDD:269869	29/60 (48%)
kay	NP_001027577.2	coiled coil	421..480	CDD:269869	28/58 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44334
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23351
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R103
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.900