DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fosl2 and CrebB

DIOPT Version :9

Sequence 1:	NP_032063.2	Gene:	Fosl2 / 14284	MGIID:	102858	Length:	326	Species:	Mus musculus
Sequence 2:	NP_001334685.1	Gene:	CrebB / 32817	FlyBaseID:	FBgn0265784	Length:	331	Species:	Drosophila melanogaster

Alignment Length:	265	Identity:	51/265 - (19%)
Similarity:	86/265 - (32%)	Gaps:	105/265 - (39%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 SSGSPAHAESYSSGGG--------------------GQQKFRVD--MPGSGSAFIPT-------- 50
            ::|.|..|.:.:.|||                    .|...:|.  :..:.|..|.|
  Fly    59 TAGGPTGATNNAQGGGVSSVLTTTANCNIQYPIQTLAQHGLQVQSVIQANPSGVIQTAAGTQQQQ 123

Mouse    51 --INAITTSQDLQWMVQP---TVI-------TSMSNPYPRSHP--YSPLPG-------------- 87
              :.|.|..|.:.::.:|   |||       ..:.|..|.:.|  ..|.|.
  Fly   124 QALAAATAMQKVVYVAKPPNSTVIHTTPGNAVQVRNKIPPTFPCKIKPEPNTQHPEDSDESLSDD 188

Mouse    88 --------LASVPGH--------------MALP-RPGVIKT--IGTTVGRRRRDE---QLSP--- 121
                    |...|.:              .:|| ..||:.:  .||..|....:.   ||.|
  Fly   189 DSQHHRSELTRRPSYNKIFTEISGPDMSGASLPMSDGVLNSQLAGTGAGGNAANSSLMQLDPTYY 253

Mouse   122 ----------------EEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELEEEKSGLQKEI 170
                            ::..||.||.::|:.||.:||.:::|..:.|:.....||.:...|.:|:
  Fly   254 LSNRMSYNTNNSGIAEDQTRKREIRLQKNREAARECRRKKKEYIKCLENRVAVLENQNKALIEEL 318

Mouse   171 AELQK 175
            ..|::
  Fly   319 KSLKE 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fosl2	NP_032063.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..131		7/42 (17%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	126..128		1/1 (100%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	129..136		3/6 (50%)
		bZIP_Fos	134..187	CDD:269869	12/42 (29%)
		coiled coil	134..186	CDD:269869	12/42 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..244
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..326
CrebB	NP_001334685.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R103
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940