DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fosb and kay

DIOPT Version :9

Sequence 1:	NP_032062.1	Gene:	Fosb / 14282	MGIID:	95575	Length:	338	Species:	Mus musculus
Sequence 2:	NP_001027577.2	Gene:	kay / 3772082	FlyBaseID:	FBgn0001297	Length:	755	Species:	Drosophila melanogaster

Alignment Length:	418	Identity:	105/418 - (25%)
Similarity:	143/418 - (34%)	Gaps:	160/418 - (38%)

- Green bases have known domain annotations that are detailed below.

Mouse    44 CAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQ------GQPLASQPPAVDPYD---- 98
            |||..      ||.|  :..:.|:..:..||.:||:...|      ||...|:.......|
  Fly   279 CAGFA------VPKV--LPNAIDVLGMGIPTGVSSLPLQQTFDLSLGQGSESEDSNASYNDTQMN 335

Mouse    99 ------------MPGTSY--------STPG---------LSAYSTGGASGSGGPSTSTTTSGPVS 134
                        ...|||        |..|         |:|.|:...|.|.|.|.:.|::.|
  Fly   336 EEQDTTDTSSAHTDSTSYQAGHIMAGSVNGGGVNNFSNVLAAVSSSRGSASVGSSNANTSNTP-- 398

Mouse   135 ARPARARPRRPREET-LTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELE 198
            ||  |...|||...| :|||||:||.|||||||.|||:||.||.:.|:.|..|.:|||:....:.
  Fly   399 AR--RGGGRRPNRSTNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMR 461

Mouse   199 SEIAELQKEKERLEFVLVAHKPGC-KIPYE---------------------EGPGPGP------- 234
            .||..|...|.:||::|..|:..| ||..:                     .|.|...
  Fly   462 KEIEVLTNSKNQLEYLLATHRATCQKIRSDMLSVVTCNGLIAPAGLLSAGSSGSGASSHHNHNSN 526

Mouse   235 -----------------------------------LAEVRDLP------GSTSAKEDGFGWLLPP 258
                                               |..::|.|      ..:|..:||
  Fly   527 DSSNGTITGMDATLNSTGRSNSPLDLKPAANIDSLLMHIKDEPLDGAIDSGSSLDQDG------- 584

Mouse   259 PPPPPLPFQSSRDAPPNLTASLFTHSEVQVLGDPFPVVSPSYTSSFVLTCPEVSAFAGAQRTSGS 323
              |||    |.|...|.::.....|...        :::|:..||..|..|..|...|.   .||
  Fly   585 --PPP----SKRITLPPMSTMPHVHLST--------ILTPTGASSGSLQTPITSTAPGG---FGS 632

Mouse   324 EQP--------------SDPLNSPSLLA 337
            ..|              .:.:|||:|.|
  Fly   633 AFPVTSNGSSINNINSIGNNMNSPTLNA 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fosb	NP_032062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..179		47/138 (34%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	157..182		17/24 (71%)
		bZIP_Fos	165..218	CDD:269869	22/52 (42%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	183..211		9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..276		17/123 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..338		9/36 (25%)
kay	NP_001027577.2	bZIP_Fos	420..481	CDD:269869	29/60 (48%)
kay	NP_001027577.2	coiled coil	421..480	CDD:269869	28/58 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44334
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.870