DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fos and CrebB

DIOPT Version :9

Sequence 1:	NP_034364.1	Gene:	Fos / 14281	MGIID:	95574	Length:	380	Species:	Mus musculus
Sequence 2:	NP_001334685.1	Gene:	CrebB / 32817	FlyBaseID:	FBgn0265784	Length:	331	Species:	Drosophila melanogaster

Alignment Length:	211	Identity:	42/211 - (19%)
Similarity:	76/211 - (36%)	Gaps:	66/211 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse    38 SSMGSPVNTQDFCADLSVSSANFI---PTVTAISTSP----DLQWLVQPTLVSSVAP-------- 87
            ::.|:....|...|..::....::   |..|.|.|:|    .::..:.||....:.|
  Fly   115 TAAGTQQQQQALAAATAMQKVVYVAKPPNSTVIHTTPGNAVQVRNKIPPTFPCKIKPEPNTQHPE 179

Mouse    88 ----------SQ------TRAPHPYGLPTQSAG------------AYARAGMVKTVSGGRAQSIG 124
                      ||      ||.|....:.|:.:|            ....:.:..|.:||.|.:
  Fly   180 DSDESLSDDDSQHHRSELTRRPSYNKIFTEISGPDMSGASLPMSDGVLNSQLAGTGAGGNAAN-- 242

Mouse   125 RRGKVEQLSP-------------------EEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETD 170
              ..:.||.|                   ::..||.||.::|:.||.:||.:::|....|:....
  Fly   243 --SSLMQLDPTYYLSNRMSYNTNNSGIAEDQTRKREIRLQKNREAARECRRKKKEYIKCLENRVA 305

Mouse   171 QLEDEKSALQTEIANL 186
            .||::..||..|:.:|
  Fly   306 VLENQNKALIEELKSL 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fos	NP_034364.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..141		7/42 (17%)
		Basic motif, required for the activation of phospholipid synthesis, but not for CDS1-binding	139..159		9/19 (47%)
		bZIP_Fos	147..200	CDD:269869	13/40 (33%)
		coiled coil	147..199	CDD:269869	13/40 (33%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	165..193		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..380
CrebB	NP_001334685.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R103
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940