DRSC/TRiP Functional Genomics Resources

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Protein Alignment MIB2 and mib2

DIOPT Version :10

Sequence 1:XP_047302550.1 Gene:MIB2 / 142678 HGNCID:30577 Length:1267 Species:Homo sapiens
Sequence 2:NP_609933.1 Gene:mib2 / 35170 FlyBaseID:FBgn0086442 Length:1049 Species:Drosophila melanogaster


Alignment Length:1047 Identity:395/1047 - (37%)
Similarity:549/1047 - (52%) Gaps:199/1047 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   342 VRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQG 406
            |||.|::||.|.|.|:.|:.:||..|.:|.||..||..:.|::.|.|.||.|.:|..|.|..|:|
  Fly    80 VRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNSLGVRLPMRKG 144

Human   407 LPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRV 471
            ..||.|||||.|:||||||||||..||||||:.|||::|||||.|:.||||:|.|..|:|||||:
  Fly   145 AKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANVAWVTGSTNVYRL 209

Human   472 GHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEG 536
            ||||.||||.:....||.|||||:|.||:..|||.........|..||:||..|:.|.|.::|:|
  Fly   210 GHKGNVDLKYITATCGGHYYKDHMPVLGQTEELQPVAPMVKPSFSVGDRVKVCLEVDALMKLQQG 274

Human   537 HGGWNPRMAEFIGQTGTVHRITDRGDVRVQF-NHETRWTFHPGALTKDTRKAGQLRGREGGGWAK 600
            ||||||||.|.:.:.||||||||:||:|||: |...||||||.||.|..                
  Fly   275 HGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVKVV---------------- 323

Human   601 MLLHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVA--GQR 663
                 ||.|||:|.:|.|.:.|::||.|||||.:.|..|||::.|||||:.||:||:...  |..
  Fly   324 -----SFRVGDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFE 383

Human   664 WTFSPSC-------LVAYRPEEDANLDVAERAREN-------KSSLSVALDKLRAQKSDPEHPGR 714
            ||.:|.|       |.......::.:|::.|..::       .|..||| ||             
  Fly   384 WTLNPKCVKLERSPLATAAERSNSMMDLSHRRADHVMTPLSGLSGSSVA-DK------------- 434

Human   715 LVVEVALGNAARALDLLRR----RPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDD 775
            ||.|.|.|:    ||.:|:    .|.|||..:.|:..:|||::.|.|:|:..|:...|.|:..|.
  Fly   435 LVREAAQGH----LDFVRQYLDVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISKGANVNAVDK 495

Human   776 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPD 840
            ||::||||||.||||...||||..|...:.:||:..:|||:...:.....||.|.:...:||:.|
  Fly   496 EGDSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQHNANVNIQD 560

Human   841 AHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQL 905
            ::.||.||.||  |...:.:||:|...||:|.|..|::||.:||||:|||:.:|.|:||..:|||
  Fly   561 SYGDTALHDAI--GKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSRQL 623

Human   906 VDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 970
            |:.:|:|||.||||||||.|.:|.:.|:.||:.::::||.:.|:|..|||.|.|.|::..||...
  Fly   624 VNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGVIERLVRLS 688

Human   971 CSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGP---------------------------- 1007
            |.|||:||:||.|:|:.:.:...|...|     :|.|                            
  Fly   689 CDVNAKDEDGDNAMHLCVIKKSNLQSAA-----EPQPEEAPEIHKFYLSLVHSSIRPEDRLMYSI 748

Human  1008 LQLLSRTWGAGCWGCQVPGDASLGPAPAPALTGVCP--------AAQLQASGLP---GSAELTVG 1061
            |..|||.      ||:|    .|..|.|.....:..        ..|.:|..||   .:.|::.|
  Fly   749 LIYLSRA------GCRV----ELNNANASIFEWITDRHIRQLIFGQQGEAESLPRNLQALEVSAG 803

Human  1062 AAVACFLALEGADVSYT---NHRGRSPLDLAAEGRVLKALQGCAQRFRERQA------------- 1110
            :|       :|.:.|.:   ...|..|..:||...            .:||.             
  Fly   804 SA-------DGEESSASAGAESNGAGPGSVAAPPP------------PQRQTFELMPKPNDIPAI 849

Human  1111 GGGAAP------------------------------GPRQTLGTPNTVTNLHVGAA--------- 1136
            |.||:|                              .|:..:.|.::.|.|..|||         
  Fly   850 GVGASPSTPSASPGVKKLNSDATPQNVSPQVAPRKKAPKPPVTTSSSSTALEAGAAGPSTSPVIV 914

Human  1137 PGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVA--SAAPA 1199
            |||.  ||:||:|:..:|.|.||||:..||||..|||||:||.|.:.::|...|..||  ::..:
  Fly   915 PGPH--ECIVCNEILPMVRFEPCQHQIACEECGIRMKKCLRCAVAIERRLTVSGRVVALPTSTSS 977

Human  1200 PGPPRQ-----LVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPI 1259
            |..|.:     |:..|:::..:.||...|.||::....:.|.||||||:.|...|..|.:||:.|
  Fly   978 PSDPTRLPSGDLLRYLENKVLEFEESHFCGICMERKRDVAFLCGHGACSHCAETLRTCHMCRKTI 1042

Human  1260 RDRIQIF 1266
            ..:|.::
  Fly  1043 LKKINLY 1049

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MIB2XP_047302550.1 PHA03247 <6..337 CDD:223021
ZZ_Mind_bomb 347..391 CDD:239079 17/43 (40%)
MIB_HERC2 418..482 CDD:461991 46/63 (73%)
SH3_15 515..580 CDD:465720 39/65 (60%)
SH3_15 607..671 CDD:465720 33/72 (46%)
ANKYR 678..947 CDD:440430 110/279 (39%)
ANK repeat 744..774 CDD:293786 10/29 (34%)
ANK repeat 776..807 CDD:293786 17/30 (57%)
ANK repeat 809..840 CDD:293786 8/30 (27%)
ANK repeat 842..876 CDD:293786 14/33 (42%)
ANK repeat 879..910 CDD:293786 17/30 (57%)
ANK repeat 912..944 CDD:293786 16/31 (52%)
Ank_2 917..993 CDD:463710 34/75 (45%)
ANK repeat 946..977 CDD:293786 14/30 (47%)
RING-HC_MIB2_rpt1 1142..1179 CDD:438386 21/36 (58%)
RING_Ubox 1217..1267 CDD:473075 19/50 (38%)
mib2NP_609933.1 MIB_HERC2 8..74 CDD:461991
ZZ_Mind_bomb 85..129 CDD:239079 17/43 (40%)
MIB_HERC2 156..220 CDD:461991 46/63 (73%)
SH3_15 253..319 CDD:465720 39/65 (60%)
SH3_15 325..391 CDD:465720 32/65 (49%)
ANKYR 398..664 CDD:440430 111/285 (39%)
ANK repeat 464..494 CDD:293786 10/29 (34%)
ANK repeat 496..527 CDD:293786 17/30 (57%)
ANK repeat 529..560 CDD:293786 8/30 (27%)
ANK repeat 596..628 CDD:293786 17/31 (55%)
ANK repeat 630..662 CDD:293786 16/31 (52%)
Ank_5 650..705 CDD:433530 25/54 (46%)
ANK repeat 664..695 CDD:293786 14/30 (47%)
PRK14959 <791..>919 CDD:184923 27/148 (18%)
RING-HC_MIB2_rpt1 918..955 CDD:438386 21/38 (55%)
RING-HC_MIBs-like 1004..1042 CDD:438183 15/37 (41%)
Blue background indicates that the domain is not in the aligned region.

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