DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Flt3 and tor

DIOPT Version :9

Sequence 1:	NP_034359.2	Gene:	Flt3 / 14255	MGIID:	95559	Length:	1000	Species:	Mus musculus
Sequence 2:	NP_476762.1	Gene:	tor / 35717	FlyBaseID:	FBgn0003733	Length:	923	Species:	Drosophila melanogaster

Alignment Length:	998	Identity:	235/998 - (23%)
Similarity:	385/998 - (38%)	Gaps:	261/998 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse   151 ANYTVLFTVNVRDTQLYVLRRPYFRKMENQDALL--------CISEGVPEPTVEWVLCSSHRESC 207
            |.|..:|...|...|..:|   ...|:.:...||        |:.:|    .:::..|   .:.|
  Fly     6 AKYAFIFWFFVGSNQGEML---LMDKISHDKTLLNVTACTQNCLEKG----QMDFRSC---LKDC 60

Mouse   208 KEEG--PAVVRKEEKVLHELFGTDIRCCARNALGRECTKLFTIDLNQAPQSTLP----------- 259
            :..|  |..:||    :.|.:..::.|...:.:      :|.||..|..:.|.|
  Fly    61 RINGTFPGALRK----VQENYQMNMICRTESEI------VFQIDWVQHSRGTEPAPNATYIIRVD 115

Mouse   260 -------QLFLKVGEPLWIRCKAIHVNHGFGLTWELEDKALE---EGSYFEMSTYSTNRTMIRIL 314
                   :..|.:.:..::....:..|....:|      ||.   :|||..::...|..|:||
  Fly   116 AVKDDNKETALYLSDDNFLILPGLESNSTHNIT------ALAMHGDGSYSLIAKDQTFATLIR-- 172

Mouse   315 LAFVSSVGRNDTGYYTCSSSKHPSQSALVTILEKGFINATSSQEEYEIDPYEKFCFSVRFKAYPR 379
                        ||       .||:...|.:|.  |:.        :.|........:.:|....
  Fly   173 ------------GY-------QPSKMGAVNLLR--FVP--------QPDDLHHIAAEIEWKPSAE 208

Mouse   380 IRCTWIFSQASFPCEQRGLEDGYSISKFCDHKNKPGEYIFYAENDDAQFTKMF-----TLNIRKK 439
            ..|  .|...|:......:::...: :|.|.|.     ::....|:.:|.|.:     |:||..:
  Fly   209 SNC--YFDMVSYSTNSVNMDEPLEV-QFRDRKK-----LYRHTVDNLEFDKQYHVGVRTVNIMNR 265

Mouse   440 PQV-LANASASQASCSSDGYPLPSWTWKKCSDKSP-NCT----EEIPEGV-----WNK------K 487
            .:. |.....:..|| .|.||   :.:..|....| |.|    :.:|..:     |.:      .
  Fly   266 LESDLQWLPIAVPSC-LDWYP---YNYTLCPPHKPENLTVTQKQYLPNILALNITWARPRYLPDN 326

Mouse   488 ANRKVFGQWVSSSTLN--------------MSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPFPF 538
            ....:|..:...:.||              ::..|....|...|.::.|.:...:.|:.......
  Fly   327 YTLHIFDLFKGGTELNYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVL 391

Mouse   539 IQDNISFYATIGLCLPFIVVLI---VLICHKYKKQFRYESQLQMIQVTG-PLDNEYFYVDFRDYE 599
            :.:.......:.:.:|...:|:   :..|.      |..|::|.:|:.. ......|::...|..
  Fly   392 LSEGNMVKLVLFIIVPICCILMLCSLTFCR------RNRSEVQALQMDAKDAKASEFHLSLMDSS 450

Mouse   600 YDLKWEFPRENLE-------------FGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKA 651
            ..|......|:||             ...|||.||||.|..    |:.|   ..|||||:||::.
  Fly   451 GLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRR----GVYK---KRQVAVKLLKDEP 508

Mouse   652 DSCEKEALMSELKMMTHLGHHDNIVNLLGACT-LSGPVYLIFEYCCYGDLLNYLRSKREKFHRTW 715
            :..:..|...|::|:..:|.|.|||.::|..| .|..:.|:.|||..|.|.|:|| :..||.:..
  Fly   509 NDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLR-EEWKFRQEQ 572

Mouse   716 TEIFKEHN---------FSFYPTFQAHS-----NSSM-----PGSREVQLHPP------------ 749
            ..|..:.|         |:..|....|.     |:||     ..|...|.|..
  Fly   573 NAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITN 637

Mouse   750 --------LDQLSGFNGNLI---------------------HSEDEIEYENQKRLAEEEE----- 780
                    |:.:....|:.|                     .|:.:.:.:|:||:.|.:|
  Fly   638 AADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCL 702

Mouse   781 --EDLN---VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIL 840
              .|..   .|.:.|||..|.|||.|||||.....|||||||||||::..:.:||.||||:||:.
  Fly   703 DSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVY 767

Mouse   841 SDSSY-VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGI-PVDANFYK 903
            .::.| ...|:.:||:||:|.|||...:||.:|||||:|:||:||.:||..|||.: |.|  ..:
  Fly   768 HENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSD--LLQ 830

Mouse   904 LIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLG-------------CQLAEAEE 955
            |::.|.:|::|...|:.::.:|:|||:.....||:|..|...||             .||..|.|
  Fly   831 LLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATNDVPERLKQLQAATE 895

Mouse   956 AMYQNMGG------NVPEHPSIY 972
            :..::..|      .||....:|
  Fly   896 SKLKSCDGLNSKVEQVPCEEELY 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Flt3	NP_034359.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..67
		ig	256..346	CDD:278476	19/110 (17%)
		PKc_like	573..950	CDD:304357	145/476 (30%)
		Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding. /evidence=ECO:0000250	592..598		0/5 (0%)
		Pkinase_Tyr	611..946	CDD:285015	136/420 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	968..1000		1/5 (20%)
tor	NP_476762.1	FN3	199..261	CDD:214495	11/69 (16%)
		STYKc	475..873	CDD:214568	134/407 (33%)
		PTKc	479..873	CDD:270623	134/403 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010