DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Foxb2 and FoxK

DIOPT Version :9

Sequence 1:	NP_032049.1	Gene:	Foxb2 / 14240	MGIID:	1347468	Length:	428	Species:	Mus musculus
Sequence 2:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	325	Identity:	95/325 - (29%)
Similarity:	130/325 - (40%)	Gaps:	91/325 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 PGKSSYS-DQKPPYSYISLTAMAIQHSAEKMLPLSDIYKFIMERFPYYREHTQR-WQNSLRHNLS 66
            |..:||: ::||||||..|...||..:.:|.|.||.||.||::.:||||:.|.: ||||:|||||
  Fly   443 PSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLS 507

Mouse    67 FNDCFIKIPRRPDQPGKGSFWALHPDCGDMFENGSFLRRRKRFKVLRADHAHLHSGSSKG-APGT 130
            .|..|||:.|..|:|||||||.:.||.|....:.|:.:||:|              ||:| .|..
  Fly   508 LNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQR--------------SSQGFRPPY 558

Mouse   131 GPGGHLHPHHPHHAHHHHHHHHHAAHHHHHHHPPQPPPPPPPHMVPYFHQQP------APAPQPP 189
            |                               .|:..|..|.||.......|      ..||..|
  Fly   559 G-------------------------------MPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSP 592

Mouse   190 HLP-------------SQPA---QQPQPQSQPPQTSHPGKMQ-----------EAAAVA------ 221
            .:.             ||.|   ||.|.|.|..||......|           :::.||
  Fly   593 GMSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQSSGVATPQTHV 657

Mouse   222 ---AAAAAAAAAAVGSVGRLSQFPPYGLGSAAAAAAAAAASTTGFKHPFAIENIIGRDYKGVLQA 283
               ||:.......||::..|.:....| |.|:........:....:|...|...:..||.|.::|
  Fly   658 EGSAASGGGGGGGVGALLALKRNHVMG-GGASQHTLHQQQAVAQQQHSEIIYEELPTDYSGHIEA 721

Mouse 284 283
Fly 722 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Foxb2	NP_032049.1	FH	13..101	CDD:214627	47/88 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..217		25/132 (19%)
		E_Pc_C	<342..>406	CDD:284226
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..428
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	47/86 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940