DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Foxm1 and FoxK

DIOPT Version :9

Sequence 1:	NP_032047.4	Gene:	Foxm1 / 14235	MGIID:	1347487	Length:	757	Species:	Mus musculus
Sequence 2:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	600	Identity:	119/600 - (19%)
Similarity:	205/600 - (34%)	Gaps:	219/600 - (36%)

- Green bases have known domain annotations that are detailed below.

Mouse    21 QNAPSETSEEEAKRSPAQPEPAPAQASQEVAESSSCKFPAGIKIINHPTTPNTQVVAIPSNADIQ 85
            |..|....::.....||...|...|..|:.        ||     :||         :|......
  Fly   304 QQQPHLQQQQHPHHPPAHHLPLQQQQQQQQ--------PA-----HHP---------LPHTPHHP 346

Mouse    86 SIITALTAKGKESGSSGPNRFILISSGGPSSHPSQPQAHSSRDSKRAEVITETLGPKPAAKGVPV 150
            ...|||..:.:.|||     .::....|.::|                 :....||     |:..
  Fly   347 LHHTALHQQQQRSGS-----IVVAPPAGAAAH-----------------LIAGDGP-----GIYS 384

Mouse   151 PKPPGAPPRQRQESYAGGEAAGCTLDNSLTNIQWLGKMSSDGLGPCSVKQELEEKE----NCHLE 211
            |.....|.::::..|                :...|.:|:....|.|.:|...:.:    |.:..
  Fly   385 PLKISIPKKEQKSPY----------------LSPTGTISAANSCPASPRQGFIQNQPNNYNNYGN 433

Mouse   212 QNRVKV-EEPSGVSTSWQDSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIA 275
            .|...: :.||..|.:.    :|:|||||..:|..||::...|::||..||::|..|:||::...
  Fly   434 NNTQDLFQTPSTASYNH----NEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKET 494

Mouse   276 KPGWKNSIRHNLSLHDMFV---RETSANGKVSFWTIHPSANRYLTLD-----------QVFKP-- 324
            ..||:|||||||||:..|:   |.....||.|||.|.|.:...| :|           |.|:|
  Fly   495 NKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKL-IDHSYKKRRQRSSQGFRPPY 558

Mouse   325 -LEPGSPQSPEHLESQQKRPNPELHRNVTIKTEIPLGARRKMKPLLPRVSSYLVPIQFPVNQSLV 388
             :...:|.||.|:::.                       |:..||                |.:|
  Fly   559 GMPRSAPVSPSHMDNS-----------------------RESSPL----------------QDIV 584

Mouse   389 LQPSVKVPLPLAASLMSSELARHSKRVRIA-PKVLLSSEGIAPLPATEPPKEEKPLL-------- 444
            ||.:...|      .||.|       .|.| |:::.:|:........:..::::..|
  Fly   585 LQSAPGSP------GMSLE-------QRAADPEIIYNSQNAHQQQQQQQQQQQQQTLSNNSNQYS 636

Mouse   445 ------------------------------GGEGLLPLLPIQ------------SIKEEE---MQ 464
                                          ||.|:..||.::            ::.:::   .|
  Fly   637 SGSPYYVTNQSSGVATPQTHVEGSAASGGGGGGGVGALLALKRNHVMGGGASQHTLHQQQAVAQQ 701

Mouse   465 PEEDIAHLERPIKVESPPLEEWPSPCASLKEELSNSWEDSSCSPTPKPKKSYCGLKSPTRCVSEM 529
            ...:|.:.|.|        .::.....:.:||...:..|::.:..||             .|||:
  Fly   702 QHSEIIYEELP--------TDYSGHIEASEEECVTTATDATVAKRPK-------------YVSEV 745

Mouse   530 LVTKRREKREVSRSR 544
            | ..|.:|...::.:
  Fly   746 LXCVRIQKHRQNKGK 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Foxm1	NP_032047.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..167		11/71 (15%)
		FH	234..309	CDD:238016	35/77 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..348		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..560		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..635
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..709
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	38/87 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820