DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp10 and Fkbp14

DIOPT Version :9

Sequence 1:	NP_034351.2	Gene:	Fkbp10 / 14230	MGIID:	104769	Length:	581	Species:	Mus musculus
Sequence 2:	NP_001246448.1	Gene:	Fkbp14 / 37449	FlyBaseID:	FBgn0010470	Length:	220	Species:	Drosophila melanogaster

Alignment Length:	211	Identity:	73/211 - (34%)
Similarity:	118/211 - (55%)	Gaps:	34/211 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse   379 VEIKTLSRPPENCNETSKIGDFIRYHYNCSL-LDGTRLFSSHDYEAPQEITLGANKVIEGLDRGL 442
            ::::.:| .||.|.:.||.||.:..||..:| .||.:..||.|.:.|....|||.:||:|.|:||
  Fly    26 LKVEVIS-TPEVCEQKSKNGDSLTMHYTGTLQADGKKFDSSFDRDQPFTFQLGAGQVIKGWDQGL 89

Mouse   443 QGMCVGERRQLIVPPHLAHGENGARGV-PGSAVLLFEVELVSREDGLPTGYLFVWYQDPSTSLFE 506
            ..|||||:|:|.:||.|.:|:.||..| |..|.|||:|||::           :....|:|::|:
  Fly    90 LNMCVGEKRKLTIPPQLGYGDQGAGNVIPPKATLLFDVELIN-----------IGNAPPTTNVFK 143

Mouse   507 DMDLNKDGEVPPEE----FSSFIKAQVNEGKGRLMPGQDP----------DKTISDMFQNQDRNQ 557
            ::|.|.|.::..||    .|.::|.|:.     .:.|||.          ||.:.::||::|:::
  Fly   144 EIDDNADKQLSREEVIVYVSEYLKKQMT-----AVEGQDSEELKNMLAENDKLVEEIFQHEDKDK 203

Mouse   558 DGKITAEELK-LKSDE 572
            :|.|:.:|.. .|.||
  Fly   204 NGFISHDEFSGPKHDE 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp10	NP_034351.2	FKBP_C	54..146	CDD:278674
		FKBP_C	166..258	CDD:278674
		FKBP_C	278..370	CDD:278674
		FKBP_C	391..482	CDD:278674	44/92 (48%)
		EF-hand_7	504..567	CDD:290234	20/76 (26%)
		EFh	505..566	CDD:238008	19/74 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..581		14/51 (27%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	578..581
Fkbp14	NP_001246448.1	FKBP_C	37..130	CDD:278674	44/92 (48%)
		EF-hand_7	140..212	CDD:290234	19/76 (25%)
		EFh	141..212	CDD:298682	19/75 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1507309at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820