DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fgfr1 and drpr

DIOPT Version :9

Sequence 1:	NP_034336.2	Gene:	Fgfr1 / 14182	MGIID:	95522	Length:	822	Species:	Mus musculus
Sequence 2:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster

Alignment Length:	244	Identity:	39/244 - (15%)
Similarity:	74/244 - (30%)	Gaps:	83/244 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse   141 TDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKN-----------G 194
            |.:|.|      |.|......:..::.:.|...:        .||.....:.|           |
  Fly   839 THDTNP------PSWPPNHNFDNPVYGMQAETRL--------LPNNMRSKMNNFDQRSTMSTDYG 889

Mouse   195 KEFKPDHRIGGYKVRY----ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHR- 254
            .:.....|:|.|.:.|    .|.::..|...|        ||.||.....|.|. ::..:..::
  Fly   890 DDCNASGRVGSYSINYNHDLLTKNLNADRTNP--------IVYNESLKEEHVYD-EIKHKEGYKD 945

Mouse   255 PILQAGLPANKTVALGSNVEFMCKVYS------DPQPHIQWLKHIEVNGSKIGPDNLPYVQILKT 313
            |:                     |:||      |...|:.:        |:......|:...:..
  Fly   946 PV---------------------KIYSKILFPEDEYDHLDY--------SRPSTSQKPHYHRMND 981

Mouse   314 AGVNTTDKEMEVLHLRNVSF---------EDAGEYTCLAGNSIGLSHHS 353
            |.:|....|.:..:::|::.         |...::.|....:..|.:.|
  Fly   982 AMLNINQDEEKPSNVKNMTVLLNKPLPPTEPEPQHECFDNTNTNLDNVS 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fgfr1	NP_034336.2	Ig1_FGFR	40..118	CDD:143174
		IG_like	41..118	CDD:214653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..162		5/20 (25%)
		I-set	160..247	CDD:254352	18/101 (18%)
		Heparin-binding	160..177		1/16 (6%)
		Ig2_FGFR	163..247	CDD:143265	18/98 (18%)
		IG_like	262..358	CDD:214653	15/107 (14%)
		Ig3_FGFR	270..359	CDD:143175	15/99 (15%)
		PTKc_FGFR1	464..765	CDD:270678
		Pkinase_Tyr	478..754	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	782..822
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900