DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lgr5 and rk

DIOPT Version :9

Sequence 1:NP_034325.2 Gene:Lgr5 / 14160 MGIID:1341817 Length:907 Species:Mus musculus
Sequence 2:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster


Alignment Length:914 Identity:271/914 - (29%)
Similarity:423/914 - (46%) Gaps:107/914 - (11%)


- Green bases have known domain annotations that are detailed below.


Mouse    19 VAAGSSPGPDAIPRGCPSHCHCELDGRM-LLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLP 82
            |.||.........|....||||  .|.: :||:.|..:|:..:|.||......|||..||:::|.
  Fly   133 VIAGKRTLHSICERWLQKHCHC--TGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLE 195

Mouse    83 ASLLHRLCFLEELRLAGNALTHIPKGAFTGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDA 147
            |:.......||||.|:.|::.::...||.||..||.|.|||..|:.:|.::.|.|..|.||:|:.
  Fly   196 ANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNG 260

Mouse   148 NHISYVPPSCFSGLHSLRHLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIADYAFGNLSSL 212
            |.:..:...|...|..||.|.|:.|....:|..|...|..|:|:.|..|.:..|.|..|..:.:|
  Fly   261 NALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNL 325

Mouse   213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIKTLSNLKELGFHSNNIRSIPERAF 277
            :||.|..|:|..:.......|.:|:.|:|:.|.:...|..:..||.|:||...||.:|.|.:...
  Fly   326 IVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTEL 390

Mouse   278 VGNPSLITIHFYDNPIQFVGVSAFQHLPELRTLTLNGASHITEFPHLTGTATLESLTLTGAKISS 342
            ..:..::.:.  .||:..:...||:.:.:||.|.|:....:..||.|.....||.|.|..|.|..
  Fly   391 PRSMQMLDMR--ANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQE 453

Mouse   343 LPQAVCDQLPNLQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKGSTFQQLFNLRSLNLAW 407
            :|..:|.|.|.|:.|:|..|.|:.:|:||.|:.|:.:||..|:|.:|:|..|..|..|..|.|::
  Fly   454 VPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSY 518

Mouse   408 NK------------------------IAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTHL 448
            |:                        |:.||..|||...:|..|:|.:|:....|.:||..|.||
  Fly   519 NRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHL 583

Mouse   449 KLTGNRALQSLIPSANFPELKIIEMPSAYQCCAFGGCENVYKISNQ------------------- 494
            |...|..|:...|...||.::.:.:..||.||||   ..:..:|:|                   
  Fly   584 KTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAF---LPLVAMSSQKKTSQVQEAVLFPSDAEFD 645

Mouse   495 ---WNKDDGNSVDDLH--KKDAGLF--------------QVQDERD-------LEDFLLDFE--- 530
               ||....|....:|  .|..|..              |:|.:..       :|::..:.:   
  Fly   646 MTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSG 710

Mouse   531 -----------------EDLKALHSVQCSPSPGPFKPCEHLFGSWLIRIGVWTTAVLALSCNALV 578
                             ||.:. .||||.|.||||.||..||..|.:|.|||...:|:|..|..|
  Fly   711 PATGYGFGTGLFSGMSTEDFQP-GSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTV 774

Mouse   579 ALTVFRTPLYISSIKLLIGVIAVVDILMGVSSAVLAAVDAFTFGRFAQHGAWWEDGIGCQIVGFL 643
            ...:..:...:...:.|:..:|..|..||:...:||.|||.|.|.|......|:..:.||:.|||
  Fly   775 VFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFL 839

Mouse   644 SIFASESSIFLLTLAALERGFSVKCSSKFEVKAPLFSLRAIVLLCVLLALTIATIPLLGGSKYNA 708
            ::.:||.|::.|.:..|||.:::..:.....:..|.....|:.:..:.||.:|.:||:|.|.|..
  Fly   840 AVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRK 904

Mouse   709 SPLCLPLPFGEPSTTG-----YMVALVLLNSLCFLIMTIAYTKLYCSLEKGELENLWDCSMVKHI 768
            ..:|||.    .:|||     |:::|:.:|...||.:...|.|:|.::...:..|..|..:.|.:
  Fly   905 FAVCLPF----ETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRM 965

Mouse   769 ALLLFANCILYCPVAFLSFSSLLNLTFISPDVIKFILLVIVPLPSCLNPLLYIVFNPHFKEDMGS 833
            |||:|.:.:.:.|:||.|.:::..|..||.:..|...:.::||.||.||.||.:....||:|..:
  Fly   966 ALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVT 1030

Mouse   834 LGKH 837
            |.||
  Fly  1031 LCKH 1034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr5NP_034325.2 LRRNT 33..70 CDD:214470 12/37 (32%)
leucine-rich repeat 68..91 CDD:275380 7/22 (32%)
LRR_RI 88..386 CDD:238064 97/297 (33%)
LRR_8 92..150 CDD:290566 25/57 (44%)
leucine-rich repeat 92..115 CDD:275380 10/22 (45%)
leucine-rich repeat 116..139 CDD:275380 10/22 (45%)
LRR_8 138..198 CDD:290566 19/59 (32%)
leucine-rich repeat 140..163 CDD:275380 7/22 (32%)
leucine-rich repeat 164..187 CDD:275380 8/22 (36%)
LRR_8 188..246 CDD:290566 18/57 (32%)
leucine-rich repeat 188..211 CDD:275380 7/22 (32%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
leucine-rich repeat 236..258 CDD:275380 6/21 (29%)
LRR_8 257..314 CDD:290566 16/56 (29%)
leucine-rich repeat 259..282 CDD:275380 7/22 (32%)
leucine-rich repeat 283..304 CDD:275380 4/20 (20%)
LRR_8 352..410 CDD:290566 23/81 (28%)
leucine-rich repeat 354..375 CDD:275378 9/20 (45%)
leucine-rich repeat 376..389 CDD:275378 5/12 (42%)
leucine-rich repeat 400..423 CDD:275378 10/46 (22%)
leucine-rich repeat 445..467 CDD:275378 8/21 (38%)
7tm_1 575..820 CDD:278431 73/249 (29%)
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 7/20 (35%)
LRR_RI 180..>383 CDD:238064 68/202 (34%)
leucine-rich repeat 183..204 CDD:275380 7/20 (35%)
LRR_8 203..263 CDD:290566 25/59 (42%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 10/22 (45%)
LRR_8 252..311 CDD:290566 19/58 (33%)
leucine-rich repeat 253..276 CDD:275380 7/22 (32%)
leucine-rich repeat 277..300 CDD:275380 8/22 (36%)
LRR_8 299..359 CDD:290566 18/59 (31%)
leucine-rich repeat 301..324 CDD:275380 7/22 (32%)
leucine-rich repeat 325..348 CDD:275380 7/22 (32%)
LRR_RI 327..567 CDD:238064 72/241 (30%)
leucine-rich repeat 349..371 CDD:275380 6/21 (29%)
LRR_8 370..425 CDD:290566 16/56 (29%)
leucine-rich repeat 372..393 CDD:275380 7/20 (35%)
leucine-rich repeat 394..415 CDD:275380 4/22 (18%)
leucine-rich repeat 418..486 CDD:275380 26/67 (39%)
leucine-rich repeat 441..464 CDD:275378 9/22 (41%)
LRR_8 487..545 CDD:290566 13/57 (23%)
leucine-rich repeat 487..510 CDD:275380 9/22 (41%)
leucine-rich repeat 511..534 CDD:275380 4/22 (18%)
LRR_8 533..589 CDD:290566 17/55 (31%)
leucine-rich repeat 535..558 CDD:275380 6/22 (27%)
leucine-rich repeat 559..580 CDD:275380 7/20 (35%)
7tm_4 764..>892 CDD:304433 34/127 (27%)
7tm_1 770..1017 CDD:278431 73/250 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 90 1.000 Domainoid score I7798
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20807
Inparanoid 1 1.050 383 1.000 Inparanoid score I2026
Isobase 1 0.950 - 0 Normalized mean entropy S5677
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171884at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm43490
orthoMCL 1 0.900 - - OOG6_106088
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2481
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.680

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