DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbln1 and frac

DIOPT Version :9

Sequence 1:	NP_034310.2	Gene:	Fbln1 / 14114	MGIID:	95487	Length:	705	Species:	Mus musculus
Sequence 2:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	216/781 - (27%)
Similarity:	297/781 - (38%)	Gaps:	245/781 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 ERPVPSRLVPLPLLLLSSLSLLAARANADISMEA--CCTDGNQMANQHRDCSLPYTSESKECRM- 63
            |.|..:.:|..|:...:.:.:     |...|..|  .|..|.|::....||     .:..||.:
  Fly   365 ENPEITEVVENPIEKTNEVPV-----NVSESQPAGKTCNSGFQLSADGTDC-----QDINECEVD 419

Mouse    64 ---------VQEQCCHNQLEELH--CATGINLASEPEGCASLHSYNSSLETIFIK--RCCHCCML 115
                     |.:|.|.|.:....  |..|.:|..:...|| |.|. :.||...:.  ||.|
  Fly   420 GPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSC-TDLENPQLNRTRCAH---- 478

Mouse   116 GKASLARDQTCEPIVMISYQCGLVFRACCVKARENSDFVQGNGADLQDPAKIPDEEDQEDPYLND 180
                     .|:.:...||:|      .|.|..|.|                   |||....:.:
  Fly   479 ---------ECQDLPEGSYRC------VCPKGYELS-------------------EDQHSCLVQE 509

Mouse   181 RCRGGGPCKQQ----------CRDTGDEV--ICSCFVGYQLQSDGVSCEDINECITGSHNCRLGE 233
                 .||..:          |..:.|..  .|.|..||  :|:..||:||:||...:|.|  ..
  Fly   510 -----SPCSTEKGVEKCSPGTCLASEDNTSFSCICPTGY--RSEAFSCQDIDECAEDTHLC--SH 565

Mouse   234 SCINTVGSFRCQRDS-----------------------------------SCGTGYELTED-NNC 262
            :|.||.|.::||...                                   :|..|:.|:.| .:|
  Fly   566 TCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLSADGKSC 630

Mouse   263 KDIDECETGIHNCPPDFICQNTLGSFRCRPKLQCKSGF----IQDALGNCIDINECLSISAPCPV 323
            :|:|||......|..  :|:|..||:.|    .|.:|:    :....|.|.||:||...:..|..
  Fly   631 EDVDECLVNNGGCQQ--VCRNLPGSYGC----ICAAGYELLKLDGIRGYCFDIDECSQRTHGCSD 689

Mouse   324 GQTCINTEGSYTCQKNVPNCGRGYHL----------------------NEEGTRCVDVDECSPPA 366
            ...|.|..|||||.     |..||.|                      ......|:|:||||...
  Fly   690 QMLCENLNGSYTCL-----CPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLAN 749

Mouse   367 EPCGKGHHCLNSPGSFRCECKAGFYFDGISRTCVDINECQRYPGRLCGHKCENTPGSFHCSCSAG 431
            ..|  .|.|.|.||.|:|.|..|:......|||.||:||....|: |...|.|.||.|.|:|..|
  Fly   750 GNC--SHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQ-CSQLCLNQPGGFACACETG 811

Mouse   432 FRLSVDGRSCEDVNECLN--SPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA-LPTGG 493
            |.|:.||..|.|::||..  ..||..|.|:.|::.|.|.|||:|:. |.::|.|:|||| |.:||
  Fly   812 FELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERGYELAK-DKLSCLDVDECAGLLSGG 875

Mouse   494 HICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ-------------------------------- 526
              ||:.|||..|:|:|.|| .||.|..:||:|.
  Fly   876 --CSHECINKAGTFECGCP-LGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDD 937

Mouse   527 ---DIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSADTFRQEKTDTVRCIKSCRPNDE 588
               |||||......||  ..|.|.:|||:|   .||..|...:|.            |:|:..||
  Fly   938 KCVDIDECQKQNGGCS--HRCSNTEGSFKC---SCPPGYELDSDQ------------KTCQDIDE 985

Mouse   589 ACVRDPVHTVSHTVIS-LPTFR-EFTR----PE--------EIIFLRAVTPLYPANQADIIFDIT 639
             |.:|....::.|.|: :..|| ||.:    ||        |...:...||.||        |.|
  Fly   986 -CDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTASSLPESPKIELKTPKYP--------DFT 1041

Mouse   640 E 640
            |
  Fly  1042 E 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbln1	NP_034310.2	ANATO	30..85	CDD:237984	15/68 (22%)
		ANATO	107..162	CDD:237984	11/56 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..175		3/18 (17%)
		cEGF	201..221	CDD:289433	9/19 (47%)
		EGF_CA	218..261	CDD:284955	16/78 (21%)
		EGF_CA	264..>300	CDD:284955	11/35 (31%)
		EGF_CA	310..356	CDD:284955	16/67 (24%)
		Self-association and FN1-binding. /evidence=ECO:0000250	358..442		36/83 (43%)
		EGF_CA	358..391	CDD:214542	15/32 (47%)
		EGF_CA	401..442	CDD:214542	18/40 (45%)
		cEGF	462..486	CDD:289433	9/23 (39%)
		vWFA	<481..524	CDD:294047	23/43 (53%)
		cEGF	506..530	CDD:289433	12/58 (21%)
		EGF_CA	527..567	CDD:284955	16/39 (41%)
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433	5/23 (22%)
		FXa_inhibition	425..458	CDD:291342	7/32 (22%)
		FXa_inhibition	476..505	CDD:291342	13/66 (20%)
		vWFA	<550..586	CDD:294047	13/37 (35%)
		FXa_inhibition	596..630	CDD:291342	4/33 (12%)
		FXa_inhibition	636..>664	CDD:291342	9/33 (27%)
		EGF_CA	676..715	CDD:284955	16/43 (37%)
		FXa_inhibition	745..780	CDD:291342	13/36 (36%)
		FXa_inhibition	786..821	CDD:291342	15/35 (43%)
		FXa_inhibition	827..862	CDD:291342	13/35 (37%)
		FXa_inhibition	874..904	CDD:291342	17/32 (53%)
		FXa_inhibition	945..980	CDD:291342	14/51 (27%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040