DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CRYAB and Hsp23

DIOPT Version :9

Sequence 1:	NP_001276736.1	Gene:	CRYAB / 1410	HGNCID:	2389	Length:	175	Species:	Homo sapiens
Sequence 2:	NP_001246694.1	Gene:	Hsp23 / 39077	FlyBaseID:	FBgn0001224	Length:	186	Species:	Drosophila melanogaster

Alignment Length:	113	Identity:	49/113 - (43%)
Similarity:	69/113 - (61%)	Gaps:	7/113 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    69 RLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTI 133
            ::.||.|.|.:||.||.|.||.|||..:.:.|.|.||||:|:||||:|.|.|:|.:|...:...:
  Fly    65 KIGKDGFQVCMDVSHFKPSELVVKVQDNSVLVEGNHEEREDDHGFITRHFVRRYALPPGYEADKV 129

Human   134 TSSLSSDGVLTVNGPRK---QVSGPERTIPITREEKPA---VTAAPKK 175
            .|:||||||||:..|:.   :..|.||.:.| ::..||   |...||:
  Fly   130 ASTLSSDGVLTIKVPKPPAIEDKGNERIVQI-QQVGPAHLNVKENPKE 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRYAB	NP_001276736.1	Crystallin	1..52	CDD:395419
		ACD_alphaB-crystallin_HspB5	67..150	CDD:107246	40/80 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..175		9/34 (26%)
Hsp23	NP_001246694.1	metazoan_ACD	67..145	CDD:107247	39/77 (51%)
Hsp23	NP_001246694.1	IbpA	<69..161	CDD:223149	43/92 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101545
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850