DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CRYAB and Hsp67Ba

DIOPT Version :9

Sequence 1:	NP_001276736.1	Gene:	CRYAB / 1410	HGNCID:	2389	Length:	175	Species:	Homo sapiens
Sequence 2:	NP_523998.1	Gene:	Hsp67Ba / 39076	FlyBaseID:	FBgn0001227	Length:	445	Species:	Drosophila melanogaster

Alignment Length:	114	Identity:	43/114 - (37%)
Similarity:	67/114 - (58%)	Gaps:	9/114 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    70 LEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTIT 134
            :.::.|.|:::||.|:..||.||.:.:.|.|.|:|:|::|.||.|||.|.|||.:|...||..:.
  Fly   122 VNRNGFQVSMNVKQFAANELTVKTIDNCIVVEGQHDEKEDGHGVISRHFIRKYILPKGYDPNEVH 186

Human   135 SSLSSDGVLTVNGP------RKQVSGPERTI---PITREEKPAVTAAPK 174
            |:|||||:|||..|      :..:...||.:   .|::::|......||
  Fly   187 STLSSDGILTVKAPPPLPVVKGSLERQERIVDIQQISQQQKDKDAQPPK 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRYAB	NP_001276736.1	Crystallin	1..52	CDD:395419
		ACD_alphaB-crystallin_HspB5	67..150	CDD:107246	37/85 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..175		7/38 (18%)
Hsp67Ba	NP_523998.1	metazoan_ACD	124..200	CDD:107247	36/75 (48%)
Hsp67Ba	NP_523998.1	DNA_pol3_delta2	<218..>381	CDD:331068	4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6558
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.980