DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CRYAB and CG4461

DIOPT Version :9

Sequence 1:	NP_001276736.1	Gene:	CRYAB / 1410	HGNCID:	2389	Length:	175	Species:	Homo sapiens
Sequence 2:	NP_648304.1	Gene:	CG4461 / 39074	FlyBaseID:	FBgn0035982	Length:	200	Species:	Drosophila melanogaster

Alignment Length:	179	Identity:	50/179 - (27%)
Similarity:	79/179 - (44%)	Gaps:	16/179 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     5 IHHPWIRRPFFPF-HSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAP-SW-----FD 62
            ::||......:|: ...|||:  :...|...|||......|....:|.......| .|     :|
  Fly    21 LYHPPYDFQLYPYLWDDSRLW--WPSPHTSRSDLLRPLDELVSRRVRNQLIQSTPYEWAHPMRWD 83

Human    63 TGLSEMRLEKDR--FSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQD-EHGFISREFHRKYRI 124
            ...|..|:..|.  |.:::||:.|.|.::.||...|.:.|.|.|..|.: .:|.:.|.|.|||.:
  Fly    84 NYYSGERVHVDEKGFRIDIDVRQFHPHDIVVKTNDDYVIVQGNHNRRDEGSNGLVERHFVRKYLL 148

Human   125 PADVDPLTITSSLSSDGVLTVNG----PRKQVSGPERTIPITREEKPAV 169
            |...:...:.|.:||||:||:..    |.|..:..||.:.:....|.|:
  Fly   149 PRGYNANEVISDISSDGILTIKAPPPPPAKYYTPGERLVRVHETGKLAL 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRYAB	NP_001276736.1	Crystallin	1..52	CDD:395419	12/47 (26%)
		ACD_alphaB-crystallin_HspB5	67..150	CDD:107246	29/89 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..175		6/28 (21%)
CG4461	NP_648304.1	metazoan_ACD	94..169	CDD:107247	26/74 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020