DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CRYAB and Hsp67Bc

DIOPT Version :9

Sequence 1:	NP_001276736.1	Gene:	CRYAB / 1410	HGNCID:	2389	Length:	175	Species:	Homo sapiens
Sequence 2:	NP_523994.1	Gene:	Hsp67Bc / 39071	FlyBaseID:	FBgn0001229	Length:	199	Species:	Drosophila melanogaster

Alignment Length:	120	Identity:	47/120 - (39%)
Similarity:	68/120 - (56%)	Gaps:	20/120 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    71 EKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITS 135
            ::..|.|:|||..|.|.||.||::.:.|.|.||||||:|:||.:||.|.|:|.:|.:.|...|.|
  Fly    77 KQGNFEVHLDVGLFQPGELTVKLVNECIVVEGKHEEREDDHGHVSRHFVRRYPLPKEFDSDAIVS 141

Human   136 SLSSDGVLTVNGP----RKQVSGPERTIPIT--------------REEKPAVTAA 172
            :||.||||.:..|    ::::.  ||.|||.              :|..||.:|:
  Fly   142 TLSEDGVLNITVPPLVSKEELK--ERIIPIKHVGPSDLFQNGNGHKEAGPAASAS 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRYAB	NP_001276736.1	Crystallin	1..52	CDD:395419
		ACD_alphaB-crystallin_HspB5	67..150	CDD:107246	38/82 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..175		10/45 (22%)
Hsp67Bc	NP_523994.1	metazoan_ACD	75..154	CDD:107247	37/76 (49%)
Hsp67Bc	NP_523994.1	IbpA	<79..170	CDD:223149	42/92 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148909
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950