Protein Alignment CRYAA and Hsp23

DIOPT Version :10

• Sequence 1: NP_000385.1
• Gene: CRYAA / 1409
• HGNCID: 2388
• Length: 173
• Species: Homo sapiens
• Sequence 2: NP_523999.1
• Gene: Hsp23 / 39077
• FlyBaseID: FBgn0001224
• Length: 186
• Species: Drosophila melanogaster
• Alignment Length: 171
• Identity: 55/171 - (32%)
• Similarity: 80/171 - (46%)
• Gaps: 34/171 - (19%)

Human    29 EGLFEYDLLPFLSSTISPYY-------------------RQSLFRTVLDSGISEVRS--DRDKFV 72
            :.|....::||    ..|||                   ||...:....||.|...|  .:|.|.
  Fly    12 DDLGRMSMVPF----YEPYYCQRQRNPYLALVGPMEQQLRQLEKQVGASSGSSGAVSKIGKDGFQ 72

Human    73 IFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADG 137
            :.:||.||.|.:|.|||||:.|.:.|.|.||:||||:|:|.|.|||.||...:...::.:||:||
  Fly    73 VCMDVSHFKPSELVVKVQDNSVLVEGNHEEREDDHGFITRHFVRRYALPPGYEADKVASTLSSDG 137

Human   138 MLTFCGPKIQTGLDATHAERAIPVSR--------EEKPTSA 170
            :||...|| ...::....||.:.:.:        :|.|..|
  Fly   138 VLTIKVPK-PPAIEDKGNERIVQIQQVGPAHLNVKENPKEA 177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRYAA	NP_000385.1	Crystallin	1..54	CDD:425732	8/43 (19%)
		ACD_alphaA-crystallin_HspB4	60..145	CDD:107245	39/86 (45%)
Hsp23	NP_523999.1	metazoan_ACD	67..145	CDD:107247	36/77 (47%)