Protein Alignment CRYAA and l(2)efl

DIOPT Version :10

• Sequence 1: NP_000385.1
• Gene: CRYAA / 1409
• HGNCID: 2388
• Length: 173
• Species: Homo sapiens
• Sequence 2: NP_523827.1
• Gene: l(2)efl / 37744
• FlyBaseID: FBgn0011296
• Length: 187
• Species: Drosophila melanogaster
• Alignment Length: 174
• Identity: 69/174 - (39%)
• Similarity: 101/174 - (58%)
• Gaps: 19/174 - (10%)

Human     9 WFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFL---------SSTISPYYRQSLFRTVLDSGISEV 64
            |:.....|...|||.||.||:||...||:..:         |..:.|::..||.:.  :|| |.:
  Fly    11 WWDELDFPMRTSRLLDQHFGQGLKRDDLMSSVWNSRPTVLRSGYLRPWHTNSLQKQ--ESG-STL 72

Human    65 RSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSAL 129
            ..|.:||.:.|||:.|||.::||||.|.||.:.|||.|:||:|||:||:|.|||:|||:|:...:
  Fly    73 NIDSEKFEVILDVQQFSPSEITVKVADKFVIVEGKHEEKQDEHGYVSRQFSRRYQLPSDVNPDTV 137

Human   130 SCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS 173
            :.|||:||:||...|  ...|.....||.:.:::     :.|||
  Fly   138 TSSLSSDGLLTIKAP--MKALPPPQTERLVQITQ-----TGPSS 174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRYAA	NP_000385.1	Crystallin	1..54	CDD:425732	17/53 (32%)
		ACD_alphaA-crystallin_HspB4	60..145	CDD:107245	44/84 (52%)
l(2)efl	NP_523827.1	metazoan_ACD	71..153	CDD:107247	43/83 (52%)