DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNBD2 and pnpla6

DIOPT Version :9

Sequence 1:	XP_011526892.1	Gene:	CNBD2 / 140894	HGNCID:	16145	Length:	617	Species:	Homo sapiens
Sequence 2:	XP_005160109.1	Gene:	pnpla6 / 560986	ZFINID:	ZDB-GENE-050107-4	Length:	1343	Species:	Danio rerio

Alignment Length:	453	Identity:	87/453 - (19%)
Similarity:	149/453 - (32%)	Gaps:	148/453 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    31 EEESEEEPECLEIDFKSRTLSVRRFG---------LQ-----GLYQLAMDIIIMIRVCKMF---R 78
            :.||.|.||            ..|||         ||     |:...|..:|::|.|...|   |
Zfish     7 DTESAEPPE------------TDRFGNIKSLVEDQLQTSMVVGIVIGAGVVIVLIAVLIFFVLRR 59

Human    79 QGLRGFREYQIIETAHWKHPIFSFWDKKMQSRVTFDTMDFIAEEGHFPPK--------------- 128
            ..||.....::.:....|.....|:.:|:..:|:..|...:.......|:
Zfish    60 MQLRKLEAQEVPKYRFRKRDKVLFYGRKIMRKVSQSTSSLVGATSSTRPRLKKKQKMLNIAKKIL 124

Human   129 -------AIQIMQKKPSWRTEDEIQ-AVCN------ILQVLDSYR---NYAEPLQLLLAKVMRFE 176
                   .:|:.:..||....|..: .|.|      :|.:|.:.|   ::.:||.|.|.|.|.|.
Zfish   125 RFKKEVPTLQMKEPPPSVLEADLTEFDVANSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFL 189

Human   177 RFGRRRVIIKKGQKGNSFYFIYLGTVAI-TKDEDGSSAFLDPHPKLLHKG----SCFGEMDVLHA 236
            :|.:...:.:.||..:|.|.:..|.:.: ...:||....:    |.::.|    |....:||:..
Zfish   190 QFQQGEYVFRPGQPDSSIYVVQDGKLELCLTGQDGKDGVV----KEVYPGDSVHSLLSILDVITG 250

Human   237 SVRRSTIVCMEETEFLVVDR--EDFFANKLDQEVQKDAQYRFEFFRKMELFASWSDE--KLWQLV 297
            ..|....|.....|...|.|  .|.|                     :.:|..:.:.  ::.|::
Zfish   251 HQRPYKTVSARAAEVSTVLRLPVDAF---------------------LSIFEKYPESLVRVVQII 294

Human   298 AMAKIERFSYGQLISKDFGESPFIMFISKGSCEVLRLLD-LGASPSYRRWIWQHLELIDGRPLKT 361
             |.:::|.:                        ||.|.: ||.:..    ::.|.......||..
Zfish   295 -MVRLQRVT------------------------VLALHNYLGLTNE----LFSHEMQPRSSPLSP 330

Human   362 HLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGD------TLPKM 418
            |.:..||:...|.          |.||.:|...:...:|..       |.||      |:|.:
Zfish   331 HPTRSSPVRHSKR----------FGSLTVPDKHREAAVQNA-------TGGDHGKEGGTIPTL 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNBD2	XP_011526892.1	Crp	151..>282	CDD:223736	30/140 (21%)
CNBD2	XP_011526892.1	CAP_ED	163..259	CDD:237999	25/102 (25%)
pnpla6	XP_005160109.1	TM_EGFR-like	31..64	CDD:213052	9/32 (28%)
		Crp	164..>302	CDD:223736	33/163 (20%)
		CAP_ED	170..291	CDD:237999	28/145 (19%)
		Crp	466..>596	CDD:223736
		CAP_ED	467..577	CDD:237999
		CAP_ED	590..698	CDD:237999
		Crp	605..>706	CDD:223736
		Pat_PNPLA6_PNPLA7	921..1226	CDD:132864
		RssA	926..1216	CDD:224666
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810