DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNBD2 and prkar1aa

DIOPT Version :9

Sequence 1:	XP_011526892.1	Gene:	CNBD2 / 140894	HGNCID:	16145	Length:	617	Species:	Homo sapiens
Sequence 2:	NP_001009989.1	Gene:	prkar1aa / 494533	ZFINID:	ZDB-GENE-050116-2	Length:	379	Species:	Danio rerio

Alignment Length:	386	Identity:	76/386 - (19%)
Similarity:	148/386 - (38%)	Gaps:	77/386 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    25 ASERQFEEESEEEPECLEIDFKSRTLSVRRFGLQGLYQLAMDIIIMIRVCKMFR--QGLRGFREY 87
            ||.....||.....||...        |::..:|   ||..|.|:.:...:..|  ..||.:.|.
Zfish     2 ASSSTSSEEERSLRECERY--------VQKHNIQ---QLLKDCIVQLCTARPERPMAYLRDYFEK 55

Human    88 QIIETAHWKHPIFSFWDKKMQSRVTFDTMDFIAEEGHFPPKAIQIMQKKPSWRTEDEI----QAV 148
            ..:|.|           |:|.|:....:.....|:...||....:..::.......|:    .|.
Zfish    56 LELEEA-----------KQMVSQQKSSSRSDSREDEVSPPMNPVVKGRRRRGAISAEVYTEEDAT 109

Human   149 CNILQVL-DSYRNYAEPLQLLLAKVM--------RFERFGRR--------RVIIKKGQKGNSFYF 196
            ..:.:|: ..|:..|...:.:...|:        |.:.|...        ..:|::|.:|::||.
Zfish   110 SYVRKVIPKDYKTMAALAKAIEKNVLFAHLDDNERSDIFDAMFSVTYIAGETVIQQGDEGDNFYV 174

Human   197 IYLGTVAITKDEDGSSAFLDPHPKLLHKGSCFGEMDVLHASVRRSTIVCMEETEFLVVDREDFFA 261
            |..|.:.:..:.:..::        :.:|..|||:.:::.:.|.:|:......:...:||:.:..
Zfish   175 IDQGEMDVYVNNEWVTS--------IGEGGSFGELALIYGTPRAATVRAKTNVKLWGIDRDSYRR 231

Human   262 NKLDQEVQKDAQYRFEFFRKMELFAS---WSDEKLWQLVAMAKIERFSYGQ--LISKDFGESPFI 321
            ..:...::|...|. ||..|:.:..|   |  |:|....|:..:: |..||  ::....|:..||
Zfish   232 ILMGSTLRKRKMYE-EFLSKVSILESLDKW--ERLTVADALETVQ-FEDGQKIVVQGQPGDEFFI 292

Human   322 MFISKGSCEVLR-------LLDLG--ASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFK 373
              |.:||..||:       .:::|  |...|    :..:.|:..||....:....|::..|
Zfish   293 --ILEGSAAVLQRRSENEEFVEVGRLAPSDY----FGEIALLMNRPRAATVVARGPLKCVK 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNBD2	XP_011526892.1	Crp	151..>282	CDD:223736	25/147 (17%)
CNBD2	XP_011526892.1	CAP_ED	163..259	CDD:237999	18/111 (16%)
prkar1aa	NP_001009989.1	DD_RIalpha_PKA	14..62	CDD:213048	14/69 (20%)
		Crp	129..>255	CDD:223736	23/134 (17%)
		CAP_ED	135..244	CDD:237999	18/116 (16%)
		Crp	247..>357	CDD:223736	26/110 (24%)
		CAP_ED	253..368	CDD:237999	24/104 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810