DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNBD2 and prkg2

DIOPT Version :9

Sequence 1:	XP_011526892.1	Gene:	CNBD2 / 140894	HGNCID:	16145	Length:	617	Species:	Homo sapiens
Sequence 2:	XP_021331649.1	Gene:	prkg2 / 100125912	ZFINID:	ZDB-GENE-060531-80	Length:	769	Species:	Danio rerio

Alignment Length:	266	Identity:	63/266 - (23%)
Similarity:	113/266 - (42%)	Gaps:	56/266 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    26 SERQFEEESEEEPECLEIDFKSRTLSVRRFGLQGLYQLAMDIIIMIRVC---KMFRQGLRGFREY 87
            |.|.::|:|.::   |..|..::...:||..:|.:..:.        .|   :.::||     ||
Zfish   153 SARVWKEQSVKK---LLTDALNKNQYLRRLEVQQVKDMV--------ECMYERTYQQG-----EY 201

Human    88 QIIETAHWKHPIFSFWDKKMQSRVTFDTMDFIAEEGHFPPKAI----------QIMQKKPSWRTE 142
            .|.:.....| :|...|.|:........:..||....|...||          :......:|..:
Zfish   202 VIKQGEPGNH-LFVLADGKLDVYQHNKLLTSIAVWTTFGELAILYNCTRTASVKAASNVKTWALD 265

Human   143 DEIQAVCNILQVL-----DSYRNYAEPLQLL-------LAKV---MRFERFGRRRVIIKKGQKGN 192
            .|:  ..||:::.     :.|||:...:.||       |.|:   :..|.:.:...||::|::||
Zfish   266 REV--FHNIMRMTAEARHEQYRNFLRSVSLLASLPGDKLTKIVDCLEVEYYNKGDYIIREGEEGN 328

Human   193 SFYFIYLGTVAITKDEDGSSAFLDPHPKLLH---KGSCFGEMDVLHASVRRSTIVCMEE-TEFLV 253
            :||.|..|.:.:|:......     .|::::   ||..|||..::...||.:.|:..|: .|.||
Zfish   329 TFYIIANGKIKVTQSTQDHE-----EPQIINTLGKGDYFGEKALISDDVRSANIIAEEDGVECLV 388

Human   254 VDREDF 259
            :|||.|
Zfish   389 IDRETF 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNBD2	XP_011526892.1	Crp	151..>282	CDD:223736	36/128 (28%)
CNBD2	XP_011526892.1	CAP_ED	163..259	CDD:237999	31/109 (28%)
prkg2	XP_021331649.1	CAP_ED	176..284	CDD:237999	22/123 (18%)
		CAP_ED	293..408	CDD:237999	32/107 (30%)
		STKc_cGK	466..725	CDD:270724
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810