Protein Alignment SREK1 and l(3)psg2

DIOPT Version :10

• Sequence 1: NP_001070667.1
• Gene: SREK1 / 140890
• HGNCID: 17882
• Length: 624
• Species: Homo sapiens
• Sequence 2: NP_647974.1
• Gene: l(3)psg2 / 38630
• FlyBaseID: FBgn0035617
• Length: 1929
• Species: Drosophila melanogaster
• Alignment Length: 680
• Identity: 165/680 - (24%)
• Similarity: 268/680 - (39%)
• Gaps: 195/680 - (28%)

Human    28 SAVTSEQMRTLFSFLGEIEELRLYPP----DNAPLAFS-SKVCYVKFRDPSSVGVAQHLTNTVFI 87
            |||..||..|     |:    :|.||    ||...:.. .:|.......|||..|.:||:..:.|
  Fly     8 SAVGMEQPAT-----GK----QLKPPEDLQDNDTNSLEPGEVVTPPHYHPSSPAVKKHLSKELMI 63

Human    88 DRALIVVPCAEGKIPEESKALSLLAPAPTMTSLMPGAGLLPIPTPNPLT--------------TL 138
            .:.|..:|.:   :.|:::..:             |:|    .|||...              :.
  Fly    64 SKTLRKLPVS---VVEQARKEN-------------GSG----GTPNAQAEDADDSEGLYSESDSS 108

Human   139 GVSLSSLGAIPAAALDPN----IATLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQL 199
            |..|.::..:..|..:..    .|||.:.|..|.:| ::|.:. .:|...:.
  Fly   109 GEDLKNVEDVQKARKEKQEEAAAATLPQAPPTPFLG-INPLRF-HMRAPCFE------------- 158

Human   200 LEFFKQVGEVKFVRMAGDE-TQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKP 263
               |.::|.:..:...|.. .:||.|.....|::...|        |.|..|.:         .|
  Fly   159 ---FPRMGFMPRMNRGGPRGMRPTFFGRPPAANRMGAP--------MMGGLPTQ---------GP 203

Human   264 PEMTPQAAAKE------LEEVMKRVREAQS-FISAAIEPE--------SGKSN-ERKGGRSRSHT 312
            |   |.|.|.:      :.....|.:..|| .|..|::|.        |..|| :.:..|:::.|
  Fly   204 P---PGAYAPQNPPPTGINSNSGRCKRLQSDVIWTALQPPVSFVFNLVSECSNTKHENCRTKAET 265

Human   313 ------RSKSRSSSKS-----HSRRKRSQSKHR--------SRSHNRSRSRQKDRRRSKSPHKK- 357
                  .||..|.:||     .:.|.|...:|:        :|||:|:::|.:.|.|||..|.|
  Fly   266 TDHNSKESKLPSETKSTEPLIENNRSRELPQHKNYVRGKTSNRSHDRTQNRGRTRERSKESHGKS 330

Human   358 ----------RSKSRE----RRKSRSRSHSRD-KRKDTREKIKEKERV----------KEKDREK 397
                      |.|.||    |||||.||..:: .|..:....|||:.|          |.::|::
  Fly   331 TENSKNKDEGRGKGRERDLFRRKSRERSQDKNLNRAKSMNLSKEKDEVGGEPRNTASGKSQERDQ 395

Human   398 EREREKEREKEKERGKNKDRDKEREKDREKDKEKD----------REREREKEHEKDRDK--EKE 450
            .|.:.|:|.:|::|.:||.|:|.:.:|:.:.|..|          |...|:|..||.::|  :||
  Fly   396 SRGKTKDRSRERDRTRNKTREKSQARDQTRSKANDAEHTRAKSRKRSSSRDKRREKSKEKLGDKE 460

Human   451 KEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRER--------RRRRSRSSSR 507
            |.:|..||:.:.:|.|..|||.:.|.........||:::.|..|::|        .|.:::|..|
  Fly   461 KNEDLSKEKLEGKSTEHSEKRNESKVKNKDTNEENANKKLRERSKDRNHSKERLHERTQNKSEER 525

Human   508 SPRTSKTIK--RKSSRSPSPRSRNK-------------KDK--KREKERDHISERRERERSTSMR 555
            .|...|...  ..|..:|:.|.::|             |||  ||.:|:......:|..:.|.|.
  Fly   526 KPEAKKVRNAIENSKEAPTDRKKDKLLGPLGEKTDERSKDKQIKRSREQSVTKCPKESGKDTLME 590

Human   556 --KSSNDRDGKEKL----EKNSTSLKEKEH 579
              ...|..||.::.    |..|.|.|.:||
  Fly   591 HPPQENGLDGSKRSSMPHESFSESAKTREH 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREK1	NP_001070667.1	RRM1_SREK1	20..99	CDD:409941	22/75 (29%)
		RRM2_SREK1	178..263	CDD:409705	12/85 (14%)
l(3)psg2	NP_647974.1	PTZ00121	<308..>573	CDD:173412	78/264 (30%)