Protein Alignment SREK1 and Srp54

DIOPT Version :10

• Sequence 1: NP_001070667.1
• Gene: SREK1 / 140890
• HGNCID: 17882
• Length: 624
• Species: Homo sapiens
• Sequence 2: NP_477347.1
• Gene: Srp54 / 34312
• FlyBaseID: FBgn0024285
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 592
• Identity: 201/592 - (33%)
• Similarity: 278/592 - (46%)
• Gaps: 102/592 - (17%)

Human    14 GLTPTSVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPP-DNAPLAFSSKVCYVKFRDPSSVGV 77
            |.|| .||||||::...|.:||:|||..:|:|||:||||. .:......|::||||:.|.:||.|
  Fly     4 GNTP-RVIQVTNIAPQATKDQMQTLFGNIGKIEEIRLYPTIRDVSCPVQSRICYVKYTDTTSVPV 67

Human    78 AQHLTNTVFIDRALIVVPCAEGKIPEESKALSLLAPAPTMTSLMPGAGLLPIPTPNPLTTLGVSL 142
            ||||||||||||||||:|..  .||||.:||.:|.....:..|......||....|.:.
  Fly    68 AQHLTNTVFIDRALIVIPVL--AIPEEYRALEMLKNGTIVPGLQKPDSKLPPEVINRIE------ 124

Human   143 SSLGAIPAAAL---DPNIATLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFK 204
               |.:|...:   ||.:........|.|....|..||:|||||:.|.::.:: ...|.|:|.|:
  Fly   125 ---GQLPQQVIKTYDPKLVEFNLPEYPALPSFYDARKIEEIRRTIIVCDVKNE-WRLDDLMECFQ 185

Human   205 QVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQ 269
            :.||||:.|.|  |.....:..:||.:|.|:..||...|..|....|.:.||..:|.||...:.:
  Fly   186 RAGEVKYARWA--EKDNKTYCMIEFCEQTSIIHALRMQGQEFKGGHLSVYHSTYSITKPEAKSNE 248

Human   270 AAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHR 334
            ||..|:||.|..|:||||.|||||:|..|...:.|..||||.:||:.|.:|:|.|        ||
  Fly   249 AAQAEIEEAMTIVKEAQSMISAAIDPVIGMLAKDKRRRSRSRSRSRDRRTSRSRS--------HR 305

Human   335 SRSHNRSRSRQKDRRRSKSPHKKRSKSRERRK-SRSRSHSRDKRKDTREKIKEKERVKEKDREKE 398
            |.|..|||               ||.|||||. ||||
  Fly   306 STSRRRSR---------------RSGSRERRSVSRSR---------------------------- 327

Human   399 REREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEK-DRDKEKEKEQDKEKEREKD 462
              |.:.|.|...|.::|   :.|.:.|.......|.|.|..:|.: .|.:.|         |.:.
  Fly   328 --RSRSRGKHSSRSRSK---RSRSRHRRSSSRSRRSRSRGGKHSRSSRSRGK---------RSRS 378

Human   463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRS-RSSSRSPRTSKTIKRKSSRSPSPR 526
            |.:....:.:..:...|........:||||..|.::..|| :.||||||:.   .::||.||.|.
  Fly   379 RHRRSTSRSRSSRSHGTGGGGSGNGKRSRSRERSKKSHRSEKHSSRSPRSR---SKRSSPSPPPA 440

Human   527 SRNKKDKKREKERDHI----SERRERERSTSMRK-SSNDRDGKEKLEKNSTSLKEKEHNKEPDSS 586
            :.:|....|.|:...:    |.||:|.|:...|| .|...|.:.|..::|...|.::       |
  Fly   441 TGSKSRSSRSKDPVIVSAKSSRRRDRSRTPETRKLKSISEDTEVKSSRSSADSKSRK-------S 498

Human   587 VSKEVDD 593
            ||.|..|
  Fly   499 VSVEKSD 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREK1	NP_001070667.1	RRM1_SREK1	20..99	CDD:409941	46/79 (58%)
		RRM2_SREK1	178..263	CDD:409705	29/84 (35%)
Srp54	NP_477347.1	RRM_SRSF11_SREK1	9..85	CDD:409704	45/75 (60%)
		RRM2_SREK1	160..242	CDD:409705	29/84 (35%)