Protein Alignment SIRPA and si:ch211-180a12.2

DIOPT Version :9

• Sequence 1: NP_001317657.1
• Gene: SIRPA / 140885
• HGNCID: 9662
• Length: 508
• Species: Homo sapiens
• Sequence 2: XP_001920945.3
• Gene: si:ch211-180a12.2 / 100150385
• ZFINID: ZDB-GENE-121214-236
• Length: 903
• Species: Danio rerio
• Alignment Length: 460
• Identity: 101/460 - (21%)
• Similarity: 178/460 - (38%)
• Gaps: 84/460 - (18%)

Human    43 VLVAAGETATLRCT-------ATSLIPVGPIQWFRGAGPGRELIYNQ---KEGHFPRVTTVSDLT 97
            |.|:.|.:..|.|:       ..||:   .|.|    ..|..:|.::   :.|.|...|...
Zfish    23 VSVSPGSSTVLNCSFALPALVDNSLL---NITW----SSGGSIIASKNHTQAGFFLNSTAFP--- 77

Human    98 KRNNMDFSIRIGNITPADAGTYYCVKFRKGSPDDVEFKSGAGTE--LSVRAKPSAPVVSGPAARA 160
                 .|.:.:.|.||...|.|.|    :.|.:|.::    .||  |::.|.|...::| |.|..
Zfish    78 -----SFPLTVFNATPHQQGVYEC----RVSYNDTDY----ATEVTLTILAPPVVSIIS-PEAVL 128

Human   161 TPQHTVSFTCESHGFSPRDITLKWFKNGNELSD---FQTN--VDPVGESVSYSIHSTAKVVLT-R 219
            ..:..|.  |.:..|||..|...|.:.||::.:   .|.|  .|.:.::||:         || .
Zfish   129 KRKSVVE--CWARSFSPPQIMFTWTRGGNKIQEPQKLQVNRTEDGLYDAVSF---------LTFI 182

Human   220 EDVHSQVI---CEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRA-ENQVNVTCQVRKFYP 280
            ..:.:|.|   |||.|..|....|.   ..:..|.|.|.:.::..|..: .:.|.::|.:..|||
Zfish   183 PQISNQNISFGCEVQHSALVKPVLE---EFTPHITVLPKVTLSVVPSSSHSSSVTLSCDISGFYP 244

Human   281 QRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTC-QVEHDGQPAVSKS 344
            ..:.:.|:.||. ..:|...:: :|:||||....:..:.........::.| .::..||...:.:
Zfish   245 NNISVLWIHNGK-KLSELPLSI-QNEDGTYRRHQYHTLTREERSRGGEVQCVALQPSGQEPANGT 307

Human   345 HDLKVSAHPKEQGSNTAAENTGSNERNIYIVVGVVCTLLVALLMAALYLVRIRQKKAQGSTSSTR 409
            .||..        .:...:|.|.|:.....|..::.:|.:..|:...:..:.|.:|.:....|..
Zfish   308 IDLST--------VDLRVQNPGLNKSAKASVAMMIISLTLVFLLCFGFSWKRRDEKLKSLNISAI 364

Human   410 LHEPE----KNAREITQVQS-----LDT----NDITYADLNLPKGKKPAPQAAEPNNHTEYASIQ 461
            :..|.    |..|....|:.     :.|    |||...|.:..:.|..|.::|...:.....|:.
Zfish   365 VLPPRVVVGKKGRVTISVEGRLAERVQTTWFLNDIPIKDTSHKEKKYGAFRSASYTSRNSSVSVL 429

Human   462 TSPQP 466
            :...|
Zfish   430 SEKNP 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIRPA	NP_001317657.1	IgV_SIRP	35..145	CDD:319346	26/113 (23%)
		IgC_SIRP_domain_2	147..250	CDD:319314	28/111 (25%)
		IgC_SIRP_domain_3	252..355	CDD:319334	22/104 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..364		4/27 (15%)
		SH2-binding. /evidence=ECO:0000255	433..436		0/2 (0%)
		SH3-binding. /evidence=ECO:0000255	443..448		1/4 (25%)
		SH2-binding. /evidence=ECO:0000255	457..460		0/2 (0%)
		SH2-binding. /evidence=ECO:0000255	474..477
		SH2-binding. /evidence=ECO:0000255	500..503
si:ch211-180a12.2	XP_001920945.3	Ig	19..114	CDD:299845	26/113 (23%)
		IG_like	22..113	CDD:214653	26/112 (23%)
		C1-set	123..205	CDD:284964	26/93 (28%)
		IgC	237..309	CDD:143166	16/73 (22%)
		IgC	515..604	CDD:143166
		IgC	609..720	CDD:143166

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I37376
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910