Protein Alignment TRPM6 and Trpm

DIOPT Version :10

• Sequence 1: NP_060132.3
• Gene: TRPM6 / 140803
• HGNCID: 17995
• Length: 2022
• Species: Homo sapiens
• Sequence 2: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Alignment Length: 2170
• Identity: 676/2170 - (31%)
• Similarity: 1005/2170 - (46%)
• Gaps: 534/2170 - (24%)

Human     2 KEQPVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDY 66
            :.||        :|||:..|.||||...||..|:..:|            | ||:     |.|.:
  Fly    35 RHQP--------RSWIETNFQKRECIKFIPCPKDDTKC------------C-CGQ-----AQITH 73

Human    67 SWTISAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEW 131
            ........|...:.|...|||...|||.:|||.||.|.|...|:|:|.|:||:.:.|:.|..|||
  Fly    74 QTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEW 138

Human   132 KMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKSHSS 196
            .:|||||:|:|.||..||.:.:|.|:...:||:|||:||||||.|.|.||||:|.|||||.....
  Fly   139 NLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQ 203

Human   197 HSLRKIWTVGIPPWGVIENQRDLIG--KDVVCLYQTLDNPLSKLTTLNSMHSHFILSDDGTVGKY 259
            ....::.::||.|||::|...:|:|  ::|.|  .::.:|.|||..||:.|::|:|.|:||..||
  Fly   204 QRTGRVVSIGIAPWGIVERNHELLGHNREVPC--HSISSPRSKLAVLNNRHAYFLLVDNGTQAKY 266

Human   260 GNEMKLRRNLEKYLSLQKIHCR---------SRQGVPVVGLVVEGGPNVILSVWETVKDKD--PV 313
            |.|:.|||.|||::|..|:|..         :....|||.||:|||.|.|.:|.|.|.|..  ||
  Fly   267 GAELILRRKLEKFISNLKLHPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPV 331

Human   314 VVCEGTGRAADLLAFTHKHLAD--EGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQILMECMVHR 376
            |||:|:|||||||||.||:.:|  |..:...:::.:|..||.||...|.||:.|:|.|::|..::
  Fly   332 VVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNK 396

Human   377 DCITIF---DADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPD 438
            :.||:|   :....|.|:||..|||||.|..:||..|||:||:.|:|||||:..|.:|.|.|...
  Fly   397 NLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNG 461

Human   439 ALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 503
            ||::||..||..||:||||||:|.||::.:||||||||||||||.||.|| |.::::||:.| :.
  Fly   462 ALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANT-LGYILRDVRPH-IP 524

Human   504 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRAL-------YNNLYRK---YKHQRHSSGNRNES 558
            .||..||.|||||:..|:|.||||.|||:.||.:       |.|..||   |::||::..|....
  Fly   525 KGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSL 589

Human   559 AESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKM 623
            ....|         |:                       ..|...|.:|:|:||:||||.|||:|
  Fly   590 VTGLL---------PF-----------------------TSEMALFEFPFNELLIWAVLTKRQQM 622

Human   624 AMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNE 688
            |:..|.|||||..|::::|.||:||||||.|..:..:..|||::|:|:|......||:.:::|:.
  Fly   623 ALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDA 687

Human   689 RMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIIL 753
            ..|..|||.||.:|||.:||.|||:...|..::|.|:|::|.|:|||.|:.|||:..|:|:.:.:
  Fly   688 EKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAM 752

Human   754 PPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQN--------ASSSKESASVK-------EYDLE 803
            |..|..|:||||.|:..:||:::    .:..:||        :....|||.:|       .|.:.
  Fly   753 PFYIRQLDFKSKEELQQMPQTEE----EHLENQNLDNDDSDRSQPDAESALLKAKRSISLRYRMG 813

Human   804 RG---------------HDEKLDEN--------------QHFGLE-----SGHQHLPWTRKVYEF 834
            .|               .|.|:.||              :.|.|.     ..||.|...:|.|||
  Fly   814 AGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEF 878

Human   835 YSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFT 899
            |:|||.|||..::||:.||::|::||||:|:..|..|||....||.|...|.||||..|||...|
  Fly   879 YTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAIT 943

Human   900 QKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAG 964
            .|..||....||..:..||.||..|...|:.:... ..||:|||:|.|:|:.|:|:...||::.|
  Fly   944 HKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTM-DIGRVIYCVDSIYWYLRILNILGVNKYLG 1007

Human   965 PYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIV--------------- 1014
            |.|||:.||..||.|.|:::|:||:||||:|:|||.|.:.|:|||.::::
  Fly  1008 PLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIAGSITAPGFLGALGH 1072

Human  1015 ------------------------------------------------------------FEPYW 1019
                                                                        |:||:
  Fly  1073 NTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGNLTNVTFQPYF 1137

Human  1020 MIYGEVYAGEID-VCS---SQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESIS 1080
            |:||||:||:|| .|.   |||.|..|.::||...::||.:..|:::|||||.|||::.::.|:|
  Fly  1138 MLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVS 1202

Human  1081 NNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKK 1145
            :.:|.:.|:..:|.|.:||.||||.|.|.|...|| :.|..:|...:.:.|.||||:|.|:||::
  Fly  1203 HQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLL-KYCVRKAKGLEVQRDNGLKLFLEKDDLER 1266

Human  1146 LHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEK-------VSFIKDSLLS 1203
            |:||||:|||.:|||:...:|.|.:||::.|:|||..|..:::::|:|       |..|:..|..
  Fly  1267 LYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRK 1331

Human  1204 LDSQ----VGHL--------------QDLSALTVD------TLKVLSAVDT-------------- 1230
            ::..    :.||              .||...|::      .::.:|..||
  Fly  1332 MEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTISISDTEGGSGPGGNGGGGG 1396

Human  1231 ---------------------------------LQEDEALLAKRKHSTCKKLPHSWSNVICAEVL 1262
                                             ::.|..:..:..|.....||....     ||:
  Fly  1397 GGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPD-----EVV 1456

Human  1263 GSMEIAGEKKYQYYSMPSSLLRSLAGGRHPPRVQRGALLEI----------------TNSKREAT 1311
            .|.|...|:..:..||.|.....:    :.|..||.:..|.                |.||...|
  Fly  1457 KSREALNEQVVRKASMQSEADSDI----YIPVSQRPSTCETVKRTPYVTVRQDTGASTESKDTLT 1517

Human  1312 NVRNDQE---------------------------RQETQS--------------SIVVSGVSPNR 1335
            .:.|:.:                           ||.|.|              .|..|.:|.|:
  Fly  1518 PMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQ 1582

Human  1336 QAHSKYGQFLLV---PSNLKRVPFSAETVLP-----LSRPSVPDVLATEQDI-----QTEVLVHL 1387
            .|.....|..|.   |.:.|..|.:..:..|     .::||...:|....:.     :.|.:.|:
  Fly  1583 LASLSRRQMSLTQSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNILLKLHSEYTSITDELESVCHM 1647

Human  1388 TGQTPVV---SDWASVDEPK---EKHEPIA-----HLLDGQDKAEQVL----------------- 1424
            .. :|.|   |:.||:|.||   .:.|..|     ||.:.::....:|
  Fly  1648 IA-SPTVSLPSNKASLDRPKTEMSRAEAAALLEKKHLKECEENDYMILEGLIESRGSIDASAQGF 1711

Human  1425 ------------PTLSCTPEPMTMSSPLSQAKIMQTGGGY-----------VNWAFSEGDETGV- 1465
                        |....|...::.|.|.....:|  |||.           .:.|.|.|...|:
  Fly  1712 EIGVSIDYSHRYPLRRETAVELSPSKPSVDGDLM--GGGEGGGAGGGDSSDTSGAGSCGAMVGIS 1774

Human  1466 --FSIK--KKWQTCLPSTCDSDSSRSEQHQKQAQDSSLSDNSTRSAQSSECSEVGPWLQPNTSFW 1526
              |.:|  :.||            |:...::|...|.|.  .||:                ||.:
  Fly  1775 SGFQLKNERPWQ------------RNSSMEQQTYPSPLV--PTRA----------------TSDF 1809

Human  1527 INPLRRYRPFARSHSFRFHKEEKLMKICKIKNLSGSSEIGQGA----WVKAKMLTKDRRLSKKKK 1587
            :||....|.|.:|       .|.|.|       :.|:|....|    ::|.         |..:.
  Fly  1810 LNPPYEGRLFKKS-------SESLQK-------NSSTETDYSAHPYRFIKQ---------SSNET 1851

Human  1588 NTQGLQVPIITVNACSQSDQLNPEPGENSISEEEYSKNWFTVSKFSHTGVEPYIHQKMKTKEIGQ 1652
            ||.      :|.:....:..|..||..:  :.:.:|....::|..:..|.....:|.::|..:|
  Fly  1852 NTS------LTGSYNVDTPSLTAEPSLD--AGDSHSATGISISVGAVGGTATARYQPIRTASVG- 1907

Human  1653 CAIQISDYLKQSQEDLSKNSLWNSRSTNLN-------RNSLLKSSIGVDK----ISASLKSPQEP 1706
                .:|..:..:|..|...|.:|....:.       |..|||....||:    .:|:...||.|
  Fly  1908 ----AADGRRLREESSSSLDLSSSGPVTMQAAPAPPVRPMLLKKQFSVDQGKPSQTAAEAVPQTP 1968

Human  1707 HHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITVYRLEESSPLNLDKSMSSWSQRGRAAM-IQVL 1770
                .|.:......:|...|    |.|| .::.:..|:|||. :.|:|:.|.::....|: |..:
  Fly  1969 ----EAAQAGQAKLISTLKP----QPFA-SKLGMNVLKESSS-STDESVGSSAKSSNPALSIPQI 2023

Human  1771 SREEMDGGLRKAMRVV--STWSEDD 1793
            |...:...:.|....:  ||.||.|
  Fly  2024 STHLVQDEIAKLSSNIKSSTESEKD 2048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPM6	NP_060132.3	LSDAT_euk	109..372	CDD:465665	126/277 (45%)
		TRPV	<657..1098	CDD:454755	189/568 (33%)
		TRPM_tetra	1170..1225	CDD:465156	17/85 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1479..1516		6/36 (17%)
		Alpha_kinase_ChaK2_TRPM6	1736..1974	CDD:341222	16/61 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1997..2022
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	126/277 (45%)
		TRPV	<872..1227	CDD:454755	129/355 (36%)
		TRPM_tetra	1291..1346	CDD:465156	14/54 (26%)