DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh7 and zip

DIOPT Version :9

Sequence 1:NP_001348536.1 Gene:Myh7 / 140781 MGIID:2155600 Length:1935 Species:Mus musculus
Sequence 2:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster


Alignment Length:1965 Identity:782/1965 - (39%)
Similarity:1192/1965 - (60%) Gaps:88/1965 - (4%)


- Green bases have known domain annotations that are detailed below.


Mouse    34 KKDVFVPDDKEEFVKAKIVSREGGKVTAE-TENGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLH 97
            |:.|:||.:.:.||.|.|....|.:|..| .|.||.|.:..|.:.:.|||||||:||||.||.|:
  Fly    79 KRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLN 143

Mouse    98 EPAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAY 162
            |.:||:|:|:||.|.:||||||||||.|||||.||:|..:::..|:|.||.|.|||:|:|:|:||
  Fly   144 EASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAY 208

Mouse   163 QYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------- 204
            :.||.|||:||||.|||||||||.|||:|||:.|.:||...:                       
  Fly   209 RNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIK 273

Mouse   205 -----SKKDQT---------------PGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIR 249
                 ..::||               ..:|.||.|::||||.||||||||||:||||||||||||
  Fly   274 VKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIR 338

Mouse   250 IHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFIS 314
            |:|.|:|.::.|:||||||||||.|.|.|.||.:|||||:|:...||..:..:: ::...|||:|
  Fly   339 INFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLS 402

Mouse   315 QGETTVASIDDSEELMATDSAFDVLGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAE-PDGT 378
            .|...|..:||..|..||..:.:::|.|.|:.|||:::..|::.||:|||:|::..:||. ||.|
  Fly   403 NGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNT 467

Mouse   379 EEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVSYAIGALAKSVYEKMFNWMVTRI 443
             .|.|.|:|:||:..|:.:....||:|||.::|||.|..:||.:|:.|:||:.||:||.|:|.||
  Fly   468 -VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRI 531

Mouse   444 NATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIE 507
            |.:|: ||:....|||:||:||||||:.|||||||||:|||||||.|||.||:||||||::||||
  Fly   532 NRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIE 596

Mouse   508 WTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKP--RNVK 570
            |.|||||:|||..||||:||.|||::|:|||.||||||.||..||...| .....|.|.  |.| 
  Fly   597 WKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH-SMHPKFMKTDFRGV- 659

Mouse   571 GKQEAHFSLVHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLF--ANYAG--ADAPA 631
                |.|::|||||.|||:...||.||.|||||.:|.|.|.|....:.|::  |...|  ..|..
  Fly   660 ----ADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALT 720

Mouse   632 DKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCN 696
            |...|...:...|:|||.|::|.|.|||..||:|:|:||||||||..|..|.:|.|||:.|||||
  Fly   721 DTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCN 785

Mouse   697 GVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHT 761
            ||||||||||:||||||.:.:|||||.:|.|..||:| |:|.:|..||::.:|::|.|.|:.|.:
  Fly   786 GVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQS 849

Mouse   762 KVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLSRMEFKKLLERRDSLLIIQWNIRAFMGVKN 826
            |:||:||:|..|||.||.::|.:|...||..||.|:|..::|.|::.:::.|||.|..|::.::|
  Fly   850 KIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRN 914

Mouse   827 WPWMKLYFKIKPLLKSAETEKEMATMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQV 891
            |.|.:||.|:||||:..:.|:::...::|..:|::.|:......:|.|.|....|.||..|..|:
  Fly   915 WQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQL 979

Mouse   892 QAEQDNLADAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDD 956
            |||.:..|:|||...:|:..|.:||..::|:..|:|:|||....|..:|:|||....:|:..:::
  Fly   980 QAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEE 1044

Mouse   957 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIVKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
            .|....|::.||...:.|:|...|::|..|:...||.||||.|:|........|..||:|...|.
  Fly  1045 EEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLA 1109

Mouse  1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER------- 1079
            |.|.|.|..:.:||..|.::::.|.:.:|:|||:|.:       :.||   |:||:||       
  Fly  1110 KLKAKHEATISELEERLHKDQQQRQESDRSKRKIETE-------VADL---KEQLNERRVQVDEM 1164

Mouse  1080 ---LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR 1141
               |.|::.||.....||::|.|..:..||..:||::::.|::|:||||:.||||.||:|.|||.
  Fly  1165 QAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSE 1229

Mouse  1142 ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ 1206
            |||.:...|.::...|:.|.|:..|||.|...:::.|||.|:.||...|.:|.||:..:..:.:|
  Fly  1230 ELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQ 1294

Mouse  1207 IDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271
            ::||::.|..|||.|...:.|..|:.:.:..:..::...::..:..|.|:.|.:.|..|.:|:.:
  Fly  1295 LENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARS 1359

Mouse  1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSA 1336
            :|..:..|||.|...::.||:|.|...|...:.......||.:.::.||||.:.|..|:..|:..
  Fly  1360 ELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQI 1424

Mouse  1337 RHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1401
            ..:.:.|:||.||:.|||...:|.|::..:::.:.:.|.|.|| ...:||||.||:|.:.::..|
  Fly  1425 ESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALE 1488

Mouse  1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
            ..|:.:.|:...|:|:|.::|:|:||..:::|........|:|||:||||||||.|...|:...|
  Fly  1489 RQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQE 1553

Mouse  1467 LESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSTGKSIHELEKIRK 1531
            .:::::|||...|::..:....:|:.:.:|..:.:.|.||.|:.||....|:..|::|||||.::
  Fly  1554 RDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKR 1618

Mouse  1532 QLEAEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDS 1596
            .||::..||::..||.|..|:..|...||.::....::::.||.|..|:|..|:.:|..::.:..
  Fly  1619 ALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRD 1683

Mouse  1597 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV 1661
            |:|.||.|.:.|..|:..|||:||||.|:|..:...|::..:|.|..|.||:.:||.....::|.
  Fly  1684 LETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAK 1748

Mouse  1662 RANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1726
            .|.::|:......||:...|:||:.:|...:..:||:|:.||.|..|.:|.:....::.:.:|::
  Fly  1749 AAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDE 1813

Mouse  1727 KKKMDADLSQLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1788
            |::::|.::.|:.|:||   |..|:|   ::::||......:..||..|:..|...|..:..:|:
  Fly  1814 KRRLEARIATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLER 1875

Mouse  1789 TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1853
            ..|:|:.:|.|.|.......|..:..|||::..||.:||.|.|......|..||.:::|||||..
  Fly  1876 QNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMN 1940

Mouse  1854 TEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1918
            .|::|:::.:.::.:|||..::|..||..:|.||:.....::.||.|.|.::..|..:....::|
  Fly  1941 IEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREIN 2005

Mouse  1919 KLRAKSRDIGAKGLN 1933
            .|:.|.|..|..||:
  Fly  2006 SLKTKLRRTGGIGLS 2020

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh7NP_001348536.1 COG5022 37..1432 CDD:227355 623/1456 (43%)
MYSc_class_II 99..766 CDD:276951 367/717 (51%)
Actin-binding 655..677 15/21 (71%)
Actin-binding 757..771 6/13 (46%)
SMC_prok_B 1173..1930 CDD:274008 232/759 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1915..1935 7/19 (37%)
zipNP_523860.2 Myosin_N 80..117 CDD:280832 14/36 (39%)
Myosin_head 133..854 CDD:278492 375/729 (51%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 367/717 (51%)
Myosin_tail_1 931..2011 CDD:279860 345/1093 (32%)
Prefoldin 1431..1515 CDD:298833 30/84 (36%)
FAM76 <1847..1926 CDD:292665 21/78 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.720

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