DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myh7 and Mhc

DIOPT Version :9

Sequence 1:	NP_001348536.1	Gene:	Myh7 / 140781	MGIID:	2155600	Length:	1935	Species:	Mus musculus
Sequence 2:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster

Alignment Length:	1918	Identity:	1084/1918 - (56%)
Similarity:	1445/1918 - (75%)	Gaps:	14/1918 - (0%)

- Green bases have known domain annotations that are detailed below.

Mouse    14 PFLRKSEKERLEAQTRPFDLKKDVFVPDDKEEFVKAKIVSREGGKVTAETENGKTVTVKEDQVMQ 78
            |:|..|.::|...|::|:|.||..::||:||.::..:|.:.:|..|:...:.|:...:|.::|.:
  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEK 79

Mouse    79 QNPPKFDKIEDMAMLTFLHEPAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYR 143
            .|||||:||||||.:|.|:.|.||:||::||.:.:||||||||||.:||||..|||.......||
  Fly    80 VNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144

Mouse   144 GKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKK- 207
            ||:|:|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.|||.:.|    |||
  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA----SKKT 205

Mouse   208 -DQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKS 271
             :....||:||||::|.||.|||||||||||||||||||||||||||.|||||.||||||||||:
  Fly   206 DEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKA 270

Mouse   272 RVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDSEELMATDSAF 336
            |||.|...||.|||||||:|...|.:.|:.|:|:|.|||..:|||:.|||||||:||...||.||
  Fly   271 RVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAF 335

Mouse   337 DVLGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCH 401
            |:||||.:||..:|::|.|:||.|.|||||:.||||||.||.||..:.:.|.|.::|:|.|.|..
  Fly   336 DILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLK 400

Mouse   402 PRVKVGNEYVTKGQNVQQVSYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFE 466
            ||:|||||:||:|:|||||:.:||||.|.|::::|.|:|.:.|.||:|:|.||:|||||||||||
  Fly   401 PRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFE 465

Mouse   467 IFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIM 531
            ||::|.||||||||||||||||||||||||||||||:|||:|.||||||||.||||||||||||:
  Fly   466 IFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGIL 530

Mouse   532 SILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVK-GKQEAHFSLVHYAGTVDYNILGWLQ 595
            ||||||.|||||||.||..||.:.|||||..||||:..| |:|.|||::.||||.|.|||.|||:
  Fly   531 SILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLE 595

Mouse   596 KNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPADKGK-GKAKKGSSFQTVSALHRENLNKLM 659
            |||||||:|||..::||..|||..:||::||.....::.| |:.|||..|.|||:.::|.||.||
  Fly   596 KNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLM 660

Mouse   660 TNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 724
            |.||||.|||||||||||.|.|||:|..||||||.||||||||||||||||||::|.||:.||:|
  Fly   661 TTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKI 725

Mouse   725 LNPAAIPEGQFID-SRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRI 788
            :.|..:   |.:: .:|..|.::..:|:..:||:.|:|||||:||:||.:||.|||||.:|::.:
  Fly   726 MCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWM 787

Mouse   789 QAQSRGVLSRMEFKKLLERRDSLLIIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMK 853
            ||.:||.|||..||||.|:|.:|.::|.|:|.::.::.|||.||:.|:||||..:..|.|:|.::
  Fly   788 QAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLE 852

Mouse   854 EEFGRVKDALEKSEAR-RKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEA 917
            |:..:.:: |..:|.: |||||.....||.||..|...:..|:..|.|.:||..:|...|..||.
  Fly   853 EKAKKAEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLEN 916

Mouse   918 KVKEMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEM 982
            :::::.|||..||:...:|..:|:|.:.|.|.||:||:||||.:.|.|::|...:::::||.:|:
  Fly   917 QLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEI 981

Mouse   983 AGLDEIIVKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047
            |..||:|.||.||||...|.:|:..::|||.|||:|.|.|.|.||||.:|:||.|||:|||||.|
  Fly   982 AHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGD 1046

Mouse  1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
            :|::|||:|||||||||::.|||.:|::|::.:::||.||:::.|::||||.:..:.|:::||||
  Fly  1047 VEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQ 1111

Mouse  1113 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1177
            |||||||||:||||.||||.||.|:||:|||||:.|||||||||||.|||:|||||||..|:|||
  Fly  1112 ARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRD 1176

Mouse  1178 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAK 1242
            ||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|:..:|:|:.:.::.|...|
  Fly  1177 LEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEK 1241

Mouse  1243 ANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLT 1307
            |..||:.:.|:..:||.:||.:||.|::||..:.:.||..||.:|.|||:|.|:.:|||::.|::
  Fly  1242 AAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKIS 1306

Mouse  1308 YTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1372
            .|.||||.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||||:|...||
  Fly  1307 LTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWR 1371

Mouse  1373 TKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1437
            :|||:|.:.|:|||||||:||..||.:|||.:|::|.||..|||||.||..|:|||.::|:|:||
  Fly  1372 SKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANA 1436

Mouse  1438 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502
            .|.|.:|||:.||||:.|||.|.::..:||::||||.|:.|||||:||.||||..|.||..:|||
  Fly  1437 IANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRREN 1501

Mouse  1503 KNLQEEISDLTEQLGSTGKSIHELEKIRKQLEAEKLELQSALEEAEASLEHEEGKILRAQLEFNQ 1567
            |||.:|:.||.:|:|..|::|||:||.||:|||||.|||:|||||||:||.||.|:||||||.:|
  Fly  1502 KNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQ 1566

Mouse  1568 IKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632
            ::.||:|::.||:||.|..::||.|.:||:|.||:||.:.:.||||:|||:|.|:||:||.|.||
  Fly  1567 VRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHA 1631

Mouse  1633 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER 1697
            |:..|||||.:|..|..|||.|..|::..||.||.:|.:.|.|||.|.||.||||.|.::||.:|
  Fly  1632 NKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADR 1696

Mouse  1698 SRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDA 1762
            .|:.|||||.:..|::..:.:||.|:...|:|::::|..|.::::|.:.|.:|:|||||||:.||
  Fly  1697 GRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDA 1761

Mouse  1763 AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELE 1827
            |.:|:||:.|||.:...|:::|.:||.||:||.||||||..|||||||.:||||.|||||||||:
  Fly  1762 ARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELD 1826

Mouse  1828 AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTN 1892
            .||:|:|::.|.:||||||:|||::|:||||||..|:||||||||.|:|.||||.|||||.|..|
  Fly  1827 GEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALN 1891

Mouse  1893 LSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925
            |:||||.|.||:|||||||:||..::|.|||.|
  Fly  1892 LAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myh7	NP_001348536.1	COG5022	37..1432	CDD:227355	792/1400 (57%)
		MYSc_class_II	99..766	CDD:276951	430/671 (64%)
		Actin-binding	655..677		18/21 (86%)
		Actin-binding	757..771		8/13 (62%)
		SMC_prok_B	1173..1930	CDD:274008	415/753 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1915..1935		5/11 (45%)
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	9/36 (25%)
		MYSc	81..777	CDD:214580	450/702 (64%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	430/671 (64%)
		Myosin_tail_1	842..1897	CDD:279860	563/1055 (53%)
		V_Alix_like	1557..1877	CDD:187408	173/319 (54%)
		ATP-synt_B	<1671..1771	CDD:304375	45/99 (45%)
		TMPIT	1739..>1825	CDD:285135	51/85 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1105	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68044
Inparanoid	1	1.050	2092	1.000	Inparanoid score	I42
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm43784
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2660
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.860