Protein Alignment CRY1 and cry

DIOPT Version :10

• Sequence 1: NP_001400387.1
• Gene: CRY1 / 1407
• HGNCID: 2384
• Length: 606
• Species: Homo sapiens
• Sequence 2: NP_732407.1
• Gene: cry / 42305
• FlyBaseID: FBgn0025680
• Length: 542
• Species: Drosophila melanogaster
• Alignment Length: 525
• Identity: 214/525 - (40%)
• Similarity: 304/525 - (57%)
• Gaps: 48/525 - (9%)

Human     2 GVNAVHWFRKGLRLHDNPALKECIQGAD---TIRCVYILDPWFAGSSNVGINRWRFLLQCLEDLD 63
            |.|.: |||.||||||||||...:...|   .:..|:|.|...||:.|||.||.||||..|:|:|
  Fly     5 GANVI-WFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFLLDSLQDID 68

Human    64 ANLRKL---NSRLFVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVI 125
            ..|:..   ..||.|..|:||.:|.||.::..:.::.||.|.||...|||.:|:.|..|..::.:
  Fly    69 DQLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFV 133

Human   126 VRISHTLYDLDKIIELNGGQPPLTYKRF------------QTLISKMEP---LEIPVETITS-EV 174
            .::||||:|...:||.|||.|||||:.|            .|..:::|.   :|:..|...| ::
  Fly   134 EKVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKL 198

Human   175 IEKCTTPLSDDHDEKYGVPSLEELGFDTDGLSSAVWPGGETEALTRLERHL--ERKAWVANFERP 237
            .|:..||   :|...||    :.:||    |:...|.||||:||..|:..|  |:.|:...|..|
  Fly   199 FEQLPTP---EHFNVYG----DNMGF----LAKINWRGGETQALLLLDERLKVEQHAFERGFYLP 252

Human   238 RMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNS-------SPPLSLYGQLLWREF 295
            .....::..||..:|.:|||||||.|.||:.:.||:|.|:..:       :....:.|||:|||:
  Fly   253 NQALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREY 317

Human   296 FYTAATNNPRFDKMEGNPICVQIPWDK-NPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARH 359
            |||.:.|||.:|:||||.||:.|||.| |...|..|..|:||||.||..|.||..|||:||..|:
  Fly   318 FYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRN 382

Human   360 AVACFLTRGDLWISWEEGMKVFEELLLDADWSINAGSWMWLSCSSFFQQFFH---CYCPVGFGRR 421
            .||.|||||.||.|||.|::.|.:.|||||||:.||:|||:| ||.|::...   ..|||...:|
  Fly   383 TVATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVS-SSAFERLLDSSLVTCPVALAKR 446

Human   422 TDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQ 486
            .||:|.||::|:|.|...|.:::::||......|:..:|||||:||:.:::.:.|.:.|:..||.
  Fly   447 LDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMKS 511

Human   487 IYQQL 491
            :...|
  Fly   512 LRNSL 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRY1	NP_001400387.1	PhrB	5..487	CDD:440184	211/516 (41%)
		LIR 1. /evidence=ECO:0000250|UniProtKB:P97784	50..54		2/3 (67%)
		LIR 2. /evidence=ECO:0000250|UniProtKB:P97784	82..87		1/4 (25%)
		LIR 3. /evidence=ECO:0000250|UniProtKB:P97784	151..156		1/16 (6%)
		LIR 4. /evidence=ECO:0000250|UniProtKB:P97784	255..260		4/4 (100%)
		LIR 5. /evidence=ECO:0000250|UniProtKB:P97784	271..276		3/4 (75%)
		LIR 6. /evidence=ECO:0000250|UniProtKB:P97784	285..290		1/4 (25%)
		LIR 7. /evidence=ECO:0000250|UniProtKB:P97784	335..339		3/3 (100%)
		Required for inhibition of CLOCK-BMAL1-mediated transcription. /evidence=ECO:0000250|UniProtKB:P97784	371..470		45/101 (45%)
		LIR 8. /evidence=ECO:0000250|UniProtKB:P97784	379..384		1/4 (25%)
		LIR 9. /evidence=ECO:0000250|UniProtKB:P97784	395..400		3/4 (75%)
		LIR 10. /evidence=ECO:0000250|UniProtKB:P97784	411..416		1/7 (14%)
		LIR 11. /evidence=ECO:0000250|UniProtKB:P97784	430..435		1/4 (25%)
		Interaction with TIMELESS. /evidence=ECO:0000250|UniProtKB:P97784	471..493		5/21 (24%)
		LIR 12. /evidence=ECO:0000250|UniProtKB:P97784	486..491		0/4 (0%)
		LIR 13. /evidence=ECO:0000250|UniProtKB:P97784	492..497		214/525 (41%)
cry	NP_732407.1	PhrB	8..513	CDD:440184	211/517 (41%)