Protein Alignment CRY1 and phr6-4

DIOPT Version :10

• Sequence 1: NP_001400387.1
• Gene: CRY1 / 1407
• HGNCID: 2384
• Length: 606
• Species: Homo sapiens
• Sequence 2: NP_477188.1
• Gene: phr6-4 / 35322
• FlyBaseID: FBgn0016054
• Length: 540
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 261/494 - (52%)
• Similarity: 337/494 - (68%)
• Gaps: 13/494 - (2%)

Human     6 VHWFRKGLRLHDNPALKECIQGADT------IRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDA 64
            ||||||||||||||||......|:.      :|.::||||.......||.||||||.|.|||||.
  Fly     9 VHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDWMQVGANRWRFLQQTLEDLDN 73

Human    65 NLRKLNSRLFVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRIS 129
            .||||||||||:||:||:||||:||.|.:..|:.|.|.||:...||||::|||...||.|....|
  Fly    74 QLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEGVRVETHCS 138

Human   130 HTLYDLDKIIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEK----Y 190
            ||:|:.:.:|..|.|:.|:||::|..::   |.|::|......|.::...||..|:.::|    |
  Fly   139 HTIYNPELVIAKNLGKAPITYQKFLGIV---EQLKVPKVLGVPEKLKNMPTPPKDEVEQKDSAAY 200

Human   191 GVPSLEELGFDTDGLSSAVWPGGETEALTRLERHLERKAWVANFERPRMNANSLLASPTGLSPYL 255
            ..|::::|....:.|....:||||||||.|:|..|:.:.|||.||:|....|||..|.|.|||||
  Fly   201 DCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSLEPSTTVLSPYL 265

Human   256 RFGCLSCRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPW 320
            :|||||.|||..||.::.|:..|:|.||:||.|||:||||:||.|...|.||:|.||..|:||||
  Fly   266 KFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYCMQIPW 330

Human   321 DKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELL 385
            .::|:.|..|..||||:|:|||||.||||||||||||||||||||||||||||||||.:|||:||
  Fly   331 QEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQRVFEQLL 395

Human   386 LDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNA 450
            ||.||::|||:|||||.|:||.|:|..|.||.||::|||.|.|||:|:|.|..:||..||:||.|
  Fly   396 LDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCIYEPWKA 460

Human   451 PEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQ 489
            ....|:...|::|.:||..:|.|....:.||:||...|:
  Fly   461 SLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYK 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRY1	NP_001400387.1	PhrB	5..487	CDD:440184	260/490 (53%)
		LIR 1. /evidence=ECO:0000250|UniProtKB:P97784	50..54		3/3 (100%)
		LIR 2. /evidence=ECO:0000250|UniProtKB:P97784	82..87		3/4 (75%)
		LIR 3. /evidence=ECO:0000250|UniProtKB:P97784	151..156		1/4 (25%)
		LIR 4. /evidence=ECO:0000250|UniProtKB:P97784	255..260		3/4 (75%)
		LIR 5. /evidence=ECO:0000250|UniProtKB:P97784	271..276		1/4 (25%)
		LIR 6. /evidence=ECO:0000250|UniProtKB:P97784	285..290		3/4 (75%)
		LIR 7. /evidence=ECO:0000250|UniProtKB:P97784	335..339		2/3 (67%)
		Required for inhibition of CLOCK-BMAL1-mediated transcription. /evidence=ECO:0000250|UniProtKB:P97784	371..470		56/98 (57%)
		LIR 8. /evidence=ECO:0000250|UniProtKB:P97784	379..384		3/4 (75%)
		LIR 9. /evidence=ECO:0000250|UniProtKB:P97784	395..400		3/4 (75%)
		LIR 10. /evidence=ECO:0000250|UniProtKB:P97784	411..416		1/4 (25%)
		LIR 11. /evidence=ECO:0000250|UniProtKB:P97784	430..435		2/4 (50%)
		Interaction with TIMELESS. /evidence=ECO:0000250|UniProtKB:P97784	471..493		7/19 (37%)
		LIR 12. /evidence=ECO:0000250|UniProtKB:P97784	486..491		1/4 (25%)
		LIR 13. /evidence=ECO:0000250|UniProtKB:P97784	492..497
phr6-4	NP_477188.1	PhrB	6..497	CDD:440184	260/490 (53%)