DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TRIM69 and Trim69

DIOPT Version :9

Sequence 1:	NP_892030.3	Gene:	TRIM69 / 140691	HGNCID:	17857	Length:	500	Species:	Homo sapiens
Sequence 2:	NP_536771.2	Gene:	Trim69 / 70928	MGIID:	1918178	Length:	500	Species:	Mus musculus

Alignment Length:	501	Identity:	395/501 - (78%)
Similarity:	460/501 - (91%)	Gaps:	2/501 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEVSTNPSSNIDPGDYVEMND-SITHLPSKVVIQDITMELHCPLCNDWFRDPLMLSCGHNFCEAC 64
            ||||:.|.||.|||:||||:| :.|||||||||||:|.|||||||||||||||||:||||||:.|
Mouse     1 MEVSSRPPSNFDPGNYVEMSDPTTTHLPSKVVIQDLTTELHCPLCNDWFRDPLMLTCGHNFCQDC 65

Human    65 IQDFWRLQAKETFCPECKMLCQYNNCTFNPVLDKLVEKIKKLPLLKGHPQCPEHGENLKLFSKPD 129
            ||.||::.:||||||:|||||||:|||||.||:|||||||||||||||||||||||||||||||:
Mouse    66 IQSFWKVHSKETFCPDCKMLCQYSNCTFNLVLEKLVEKIKKLPLLKGHPQCPEHGENLKLFSKPE 130

Human   130 GKLICFQCKDARLSVGQSKEFLQISDAVHFFTEELAIQQGQLETTLKELQTLRNMQKEAIAAHKE 194
            ||:|||||||||||:||||:|||||:||.||||||||.|.||:|||||||:||.:||:||:|:|:
Mouse   131 GKMICFQCKDARLSMGQSKDFLQISEAVRFFTEELAIYQSQLQTTLKELQSLRTIQKDAISAYKD 195

Human   195 NKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQA 259
            ||:.|||::|:||||||||||:||||||.:||:|||.||||||:||:|:|||||:|||||.:|||
Mouse   196 NKIQLQQNLSLEFLKLHQFLHNKEKDILNDLRDEGKLLNEEMEVNLNQIQEQCLVAKDMLATIQA 260

Human   260 KTEQQNSFDFLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSP 324
            :.|||||||||.|||.|:.|:|:|||.:..|:||::||:||::||||||::|:|||..|.||.|.
Mouse   261 RMEQQNSFDFLTDITKLIESMEKGMKTIVPRQLIAKKLSLGRFKGPIQYIIWKEMQAILSPGPSQ 325

Human   325 LTLDPKTAHPNLVLSKSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTK 389
            |||||||||||||||||||||.|.|:|::|||||||||||||||||:||||||||||:||.||||
Mouse   326 LTLDPKTAHPNLVLSKSQTSVCHCDVKQVMPDDPERFDSSVAVLGSKGFTSGKWYWEIEVGKKTK 390

Human   390 WTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQL 454
            ||:|||||||||||||||||||||||||||||||||||||||.|||| .:|.:||:||||||||:
Mouse   391 WTIGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSRSLTL-GDLRRVGVYLDYEGGQV 454

Human   455 SFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHPQ 500
            |||||.||||:||||:.|.|||:||.||||||||||||||||:|||
Mouse   455 SFYNATTMTHLYTFSSVFQEKLFPYLCPCLNDGGENKEPLHIVHPQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRIM69	NP_892030.3	Necessary for nuclear localization. /evidence=ECO:0000250	1..152		124/151 (82%)
		RING	41..81	CDD:302633	31/39 (79%)
		iSH2_PI3K_IA_R	168..299	CDD:304922	90/130 (69%)
		SPRY_PRY_TRIM69	311..497	CDD:293990	155/185 (84%)
Trim69	NP_536771.2	Necessary for nuclear localization	1..153		124/151 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		14/20 (70%)
		RING	42..82	CDD:302633	31/39 (79%)
		SPRY	312..497	CDD:295394	155/185 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83973585
Domainoid	1	1.000	386	1.000	Domainoid score	I11897
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18827
Inparanoid	1	1.050	847	1.000	Inparanoid score	I7365
Isobase	1	0.950	-	0	Normalized mean entropy	S6049
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39897
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0013701
OrthoInspector	1	1.000	-	-		oto112394
orthoMCL	1	0.900	-	-		OOG6_108884
Panther	1	1.100	-	-	LDO	PTHR24103
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11368
SonicParanoid	1	1.000	-	-		X48
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	16.380