Protein Alignment TRIM69 and ZK1240.8

DIOPT Version :9

• Sequence 1: NP_892030.3
• Gene: TRIM69 / 140691
• HGNCID: 17857
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_494242.1
• Gene: ZK1240.8 / 191542
• WormBaseID: WBGene00022872
• Length: 292
• Species: Caenorhabditis elegans
• Alignment Length: 338
• Identity: 77/338 - (22%)
• Similarity: 123/338 - (36%)
• Gaps: 90/338 - (26%)

Human    41 CPLCN------DWFRDPLMLSCGHNFCEACIQDFWRLQAKETFCP-ECKMLCQYNNCTFNPVLDK 98
            |.:||      |..|.|.:|.|||:.|:.|....  :......|| :|....:..|..
 Worm     6 CEVCNEDYSNLDESRAPRVLKCGHSICQNCAVKL--ISNSVILCPKKCSETTEVQNGN------- 61

Human    99 LVEKIKK-------LPLLKGH-----PQCPEHGENLKLF--SKPD----GKLICFQCKDARLSVG 145
             ||.::|       :.:::..     |:|.||..|:..|  |:.|    .||:|..|::..:..|
 Worm    62 -VESLQKNFGLMQAMEMMEASSSNSPPKCKEHRYNIAEFLCSEHDCPSIDKLMCRTCEEFGVHTG 125

Human   146 QSKEFL-----QISDAVHFFTEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSM 205
            .:|..:     :|.|.:....:::.:........|:|.:...:.::..|....|.|.|
 Worm   126 HTKVLMSVEAGKIRDVLECRLKQMKLNAESFTVQLEEFREAMSNRQLFIEKLSEIKYH------- 183

Human   206 EFLKLHQFLHSKEK---DILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSF 267
             |.::.|.:..:||   |.||....|....|:|.|.|:.:||: |||         .|.||...|
 Worm   184 -FSRIRQLVDEREKRITDKLTFNTTEIYKCNKETESNMKRLQD-CLL---------EKIEQTTKF 237

Human   268 DFLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPL---TLDP 329
            ..:.|...|...::.|              .|..|..||...            .||.   |:|.
 Worm   238 SKISDYQLLQADIDLG--------------GLTWYHSPITQK------------FSPADTKTMDV 276

Human   330 KTAHPNLVLSKSQ 342
            |......|:.|.|
 Worm   277 KLPAFKFVVKKQQ 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIM69	NP_892030.3	Necessary for nuclear localization. /evidence=ECO:0000250	1..152		33/140 (24%)
		RING	41..81	CDD:302633	14/46 (30%)
		iSH2_PI3K_IA_R	168..299	CDD:304922	30/133 (23%)
		SPRY_PRY_TRIM69	311..497	CDD:293990	8/35 (23%)
ZK1240.8	NP_494242.1	RING_Ubox	3..48	CDD:388418	12/43 (28%)
		modified RING-HC finger (C3HC3D-type)	6..47	CDD:319361	12/42 (29%)
		Bbox_SF	86..135	CDD:381767	14/48 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	65	1.000	Inparanoid score	I4419
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960