Protein Alignment CRX and hbn

DIOPT Version :10

• Sequence 1: NP_000545.1
• Gene: CRX / 1406
• HGNCID: 2383
• Length: 299
• Species: Homo sapiens
• Sequence 2: NP_788420.1
• Gene: hbn / 47894
• FlyBaseID: FBgn0008636
• Length: 409
• Species: Drosophila melanogaster
• Alignment Length: 276
• Identity: 89/276 - (32%)
• Similarity: 119/276 - (43%)
• Gaps: 71/276 - (25%)

Human    36 PRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQ 100
            |||.||.|||||..||.:||..|.|||||||:.||::|::::|.|:||||||:|||||.|::.:.
  Fly   150 PRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKF 214

Human   101 QKQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPLGISDSYSPP--LPGPSGSPTTAVATVSIW 163
            ..|.               |||.. .|...:...||||.   .||  |||..||..:     ..|
  Fly   215 MNQD---------------KAGYL-LPEQGLPEFPLGIP---LPPHGLPGHPGSMQS-----EFW 255

Human   164 SP-------------ASESPLPEAQRA----------------------GLVASGPSLTSAPYAM 193
            .|             |:...||:...|                      |:..:|.:..:|..:.
  Fly   256 PPHFALHQHFNPAAAAAAGLLPQHLMAPHYKLPNFHTLLSQYMGLSNLNGIFGAGAAAAAAAASA 320

Human   194 TYAPASAFCSSPSAYGSPSSYFSGLDPYLSP-MVPQLGGPALSPLSGPSVGPSL---------AQ 248
            .|....:..:..||....|...|...|..|| :||....|..:|.:|.:.|..|         ||
  Fly   321 GYPQNLSLHAGLSAMSQVSPPCSNSSPRESPKLVPHPTPPHATPPAGGNGGGGLLTGGLISTAAQ 385

Human   249 SPTSLSGQSYGAYSPV 264
            ||.|.:|.|..|.:||
  Fly   386 SPNSAAGASSNASTPV 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRX	NP_000545.1	Homeodomain	40..93	CDD:459649	33/52 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..155		18/63 (29%)
		TF_Otx	164..249	CDD:427350	24/129 (19%)
hbn	NP_788420.1	Homeodomain	154..210	CDD:459649	35/55 (64%)