Protein Alignment CRX and otx5

DIOPT Version :10

• Sequence 1: NP_000545.1
• Gene: CRX / 1406
• HGNCID: 2383
• Length: 299
• Species: Homo sapiens
• Sequence 2: NP_851848.2
• Gene: otx5 / 353179
• ZFINID: ZDB-GENE-030508-1
• Length: 289
• Species: Danio rerio
• Alignment Length: 312
• Identity: 173/312 - (55%)
• Similarity: 208/312 - (66%)
• Gaps: 36/312 - (11%)

Human     1 MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAKTQYPD 65
            ||:||.. ||||||.|.|:|..:||:|.||.||:.|||||||||||||:||:.|||||:||:|||
Zfish     1 MMSYMKQ-PHYSVNGLTLTGTGMDLLHSAVGYPNTPRKQRRERTTFTRAQLDVLEALFSKTRYPD 64

Human    66 VYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRKAGTSPRPSTD 130
            ::.|||||||||||||||||||||||||||||:|||      ..||.|.||.|:|  :||...:.
Zfish    65 IFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQ------TSGQTKPRPPKKK--SSPARDSS 121

Human   131 VCPDPLGISDSYSPPLPGPSG--SPTTAVATVSIWSPASESPLPEAQRAGLVASGPS---LTSAP 190
            ........|..||||.|.|..  :|:::.||||||||||.||||:.      .|.||   |..:.
Zfish   122 ASEPSASTSGPYSPPPPPPGTAITPSSSSATVSIWSPASISPLPDP------LSAPSTACLQRSS 180

Human   191 YAMTYAPASAFCSSPSAYGSPSSYFSGLD--PYLSPMVPQL--GGPALSPLSGPSVGPSLAQSPT 251
            |.|||:.|.|:..|   |.:.||||:|||  .|||||.|||  .|.||||:||     :|:|||.
Zfish   181 YPMTYSQAPAYGQS---YAASSSYFTGLDCSSYLSPMHPQLSASGGALSPMSG-----ALSQSPA 237

Human   252 SLSGQSYGA----YSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL 299
            |||.|.|.|    :..||.|::||.|..||..:|..|.||||||::||||:|
Zfish   238 SLSSQGYTAASLGFGTVDCLDYKDQTSAWKLNFNAADCLDYKDQNSWKFQVL 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRX	NP_000545.1	Homeodomain	40..93	CDD:459649	44/52 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..155		25/63 (40%)
		TF_Otx	164..249	CDD:427350	43/91 (47%)
otx5	NP_851848.2	Homeodomain	39..94	CDD:459649	46/54 (85%)
		TF_Otx	157..231	CDD:427350	42/87 (48%)