Protein Alignment CRX and Gsc

DIOPT Version :10

• Sequence 1: NP_000545.1
• Gene: CRX / 1406
• HGNCID: 2383
• Length: 299
• Species: Homo sapiens
• Sequence 2: NP_001137762.2
• Gene: Gsc / 33240
• FlyBaseID: FBgn0010323
• Length: 473
• Species: Drosophila melanogaster
• Alignment Length: 219
• Identity: 71/219 - (32%)
• Similarity: 98/219 - (44%)
• Gaps: 65/219 - (29%)

Human     1 MMAYMNPGPHY------------------SVNALALSG--------------PSVDLMHQAVPYP 33
            ::||.|..|:|                  |..|..|||              |.:...|....:.
  Fly   264 LVAYPNFYPNYMHAAAVAHVAAAQMQAHVSGAAAGLSGHGHHPHHPHGHPHHPHLGAHHHGQHHL 328

Human    34 S------APRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRA 92
            |      .|:::||.||.||..|||:|||.|.||.||||..||::|||::|.|.||:||||||||
  Fly   329 SHLGHGPPPKRKRRHRTIFTEEQLEQLEATFDKTHYPDVVLREQLALKVDLKEERVEVWFKNRRA 393

Human    93 KCRQQRQQQKQQ----QQPPGGQAKARPAKRKAGTSPRPS----TDVCPDPLGISDSYSPPL--- 146
            |.|:|:::::::    |:...|..........:||:....    |..||.    ||.||..|
  Fly   394 KWRKQKREEQERLRKLQEEQCGSTTNGTTNSSSGTTSSTGNGSLTVKCPG----SDHYSAQLVHI 454

Human   147 -PGPSGSPTTAVATVSIWSPASES 169
             ..|:|           :|.|.||
  Fly   455 KSDPNG-----------YSDADES 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRX	NP_000545.1	Homeodomain	40..93	CDD:459649	35/52 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..155		17/73 (23%)
		TF_Otx	164..249	CDD:427350	4/6 (67%)
Gsc	NP_001137762.2	Homeodomain	341..397	CDD:459649	37/55 (67%)