Protein Alignment CRX and Vsx1

DIOPT Version :10

• Sequence 1: NP_000545.1
• Gene: CRX / 1406
• HGNCID: 2383
• Length: 299
• Species: Homo sapiens
• Sequence 2: NP_572232.2
• Gene: Vsx1 / 31470
• FlyBaseID: FBgn0263511
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 204
• Identity: 64/204 - (31%)
• Similarity: 84/204 - (41%)
• Gaps: 33/204 - (16%)

Human    33 PSAPRKQRRE--RTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCR 95
            |...:|.:|.  ||.||.|||||||..|.:..||||.|||.:::|..|.|.|:|||::|||||.|
  Fly   387 PGGKKKNKRRHGRTIFTSSQLEELEKAFKEAHYPDVSARELLSMKTGLAEDRIQVWYQNRRAKWR 451

Human    96 QQRQQQKQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPL-GISDSYSPPLPGPSGSPTTAVAT 159
            :..:....                        ||.:....| |....:|.|||...........:
  Fly   452 KTEKCWGH------------------------STKMAEYGLYGAMVRHSLPLPETIIKSAKEDES 492

Human   160 VSIWSPASESPLPEAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSP 224
            |:.|.........||  |.|:.|..|....|   |....:...|:.|.:.||.|.|| :...|..
  Fly   493 VAPWLLGMHKKSLEA--AELLKSDESDRETP---TSDDTNTSYSAGSTHNSPISSFS-ISRLLFD 551

Human   225 MVPQLGGPA 233
            ..|...|.|
  Fly   552 APPPAAGSA 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRX	NP_000545.1	Homeodomain	40..93	CDD:459649	30/54 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..155		10/62 (16%)
		TF_Otx	164..249	CDD:427350	19/70 (27%)
Vsx1	NP_572232.2	Homeodomain	395..452	CDD:459649	32/56 (57%)