DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ankrd6 and dgo

DIOPT Version :9

Sequence 1:	NP_001012453.1	Gene:	Ankrd6 / 140577	MGIID:	2154278	Length:	712	Species:	Mus musculus
Sequence 2:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster

Alignment Length:	665	Identity:	160/665 - (24%)
Similarity:	257/665 - (38%)	Gaps:	195/665 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse    72 DDGDQTALHRATVVGNTEILTALIREGC-ALDRQDKDGNTALHEAAWHGFSQSAKLL-------V 128
            |..:.|:||.|...|:...:..|:.... .|.|:...|||.|||||..|||:..||:       .
  Fly    22 DSSNWTSLHEAVAAGDDRRVEGLLFSNADRLARESVQGNTPLHEAASRGFSRCVKLICTPPTPPA 86

Mouse   129 KAGANVLAR--------------------------------NKAGNTALHLACQNSHSQSTRILL 161
            .:|....|:                                |..|.:|||||.||.|:||:|.||
  Fly    87 SSGVGKAAKGQKDKDKDKNKGRVKVAHQTIEALHNSALGIANNEGLSALHLAAQNGHNQSSRELL 151

Mouse   162 LGGSRADLKNNAGDTCLHVAARYNHLSVVRLLLNAFCSVHEKNQAGDTALHVAAALNHKKVVKVL 226
            |.|:..|::||.|||.||.|.||.|..|.|:||:|.|..::.|..||||||:..|:..:|:.::|
  Fly   152 LAGADPDVRNNYGDTPLHTACRYGHAGVSRILLSALCDPNKTNLNGDTALHITCAMGRRKLTRIL 216

Mouse   227 LEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQILRFSRGRSLRKRRERLKEERRAQSVP 291
            |||.|...|.|..|..|:..|...|..|:..:|         :..:.:|.|:|:.||
  Fly   217 LEADARLGIKNAQGDCPMHIAIRKNYREIIEIL---------NTPKKIRNRKEKPKE-------- 264

Mouse   292 RDEVAQSKGSVSAGDTPSSEQAVPQKEEARRDCPPASQEPRKDERRRKSRPEVSALSDPTPAADQ 356
                   .||                              |.|:.|.:.|..|
  Fly   265 -------GGS------------------------------RSDKDRDRERDVV------------ 280

Mouse   357 QPGHQKNLHSHHHPKKKSRHRCWSP------PPPHGFRAYQLYTLYR-----GED------GKVM 404
                .|.::             |||      |.|..|.:.:|.||.:     ||.      |.:.
  Fly   281 ----DKGIN-------------WSPYGCHYFPDPRAFPSPKLETLPKEPLKSGEQYFLDLAGHIH 328

Mouse   405 QAPI---KGCRCEPLINKLENQLEATVEEIRAELGSVQDKVNAKLGQMESKTQHQMCVLDKLMVE 466
            :.|:   ..|.|.|....:||:|....:.::..:...::::..|:..:..||..|:..|.:.|:|
  Fly   329 KGPVSVGNTCYCGPFFRHIENKLNCNRKSLKKYVHKTKERLGHKVQALAIKTNDQIEQLTRTMIE 393

Mouse   467 RLSAERTECMNRLQQHAAAEKQEGEKRQMSLVDELKA----WCMLKIQSLEL--------RLSG- 518
                :|..|.:: :||.:...:.||..:.:...:.|:    ..|.:.:||||        ||:.
  Fly   394 ----DRLRCESK-RQHLSEFLRRGEPMRSTFDQQNKSSRIERTMSRCRSLELLENNHEGGRLTNS 453

Mouse   519 -----------ESRTFRAKSTPPPSDSTPAVDQPVVAAGPGAASDSSSQVVRPKDKALNASAAHS 572
                       |:...|:......|||....::         |.|.....|..||:.
  Fly   454 RSVDVLEDQAVEAIVHRSAEVQVDSDSDDDSNE---------ARDEEEAEVGDKDQV-------- 501

Mouse   573 HQQELPPSDCTGSGLRKIKAPGASRCDQQTGSCVNRGTQTKKSGRSGQTKHRGQQPTASSPSGQQ 637
             |:|..|.:  .|.|.::|. ...:..::.|..:.:.|...:  |..:.:.:.|..:.|.|....
  Fly   502 -QEEAEPEE--HSKLDELKL-DFLKVSERLGVLLEKTTLIME--RDSEQESKRQLSSLSPPYNPH 560

Mouse   638 PSAASSDVRDASQAL 652
            |.|.|:.:|:..:::
  Fly   561 PRAESAQLREDKESV 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ankrd6	NP_001012453.1	ANK 1	9..38
		PHA03095	29..>265	CDD:222980	81/232 (35%)
		ANK repeat	41..72	CDD:293786	160/665 (24%)
		ANK 2	41..70
		ANK repeat	74..105	CDD:293786	8/31 (26%)
		ANK 3	74..103		7/29 (24%)
		ANK repeat	107..138	CDD:293786	15/69 (22%)
		ANK 4	107..136		14/35 (40%)
		ANK 5	140..169		16/28 (57%)
		ANK repeat	141..171	CDD:293786	17/29 (59%)
		ANK repeat	173..204	CDD:293786	15/30 (50%)
		ANK 6	173..202		15/28 (54%)
		ANK repeat	206..237	CDD:293786	14/30 (47%)
		ANK 7	206..235		13/28 (46%)
		ANK 8	239..268		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..382		15/110 (14%)
		DUF2967	520..>643	CDD:371408	23/122 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..647		24/125 (19%)
dgo	NP_610614.1	ANK	22..184	CDD:238125	55/161 (34%)
		ANK repeat	24..55	CDD:293786	7/30 (23%)
		Ank_2	29..161	CDD:289560	40/131 (31%)
		ANK repeat	59..128	CDD:293786	15/68 (22%)
		ANK	126..249	CDD:238125	56/122 (46%)
		ANK repeat	130..161	CDD:293786	17/30 (57%)
		Ank_2	135..227	CDD:289560	47/91 (52%)
		ANK repeat	163..194	CDD:293786	15/30 (50%)
		ANK repeat	196..227	CDD:293786	14/30 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BHC7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_111903
Panther	1	1.100	-	-	LDO	PTHR24203
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10493
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860