Protein Alignment Eya2 and eya

DIOPT Version :10

• Sequence 1: NP_034295.1
• Gene: Eya2 / 14049
• MGIID: 109341
• Length: 532
• Species: Mus musculus
• Sequence 2: NP_723188.1
• Gene: eya / 33916
• FlyBaseID: FBgn0000320
• Length: 766
• Species: Drosophila melanogaster
• Alignment Length: 645
• Identity: 266/645 - (41%)
• Similarity: 349/645 - (54%)
• Gaps: 146/645 - (22%)

Mouse     6 TSPSLATSSDWSEH-----------GAAVGTLSDREGIAKSAAL--------SVPQLFVKSHPRV 51
            :|.||||:|.:::.           |...|.:|..:|:...|.:        :.....|||..|
  Fly   150 SSCSLATASSFAQSAGSSFSTYQQAGGTSGGVSGEDGVVGGATVMSHWTHDGTGSSAAVKSESR- 213

Mouse    52 PPGQ--------------------------------SSTAMAA---------YGQTQYSTGIQQA 75
            .|||                                :|:|:||         :....|::..|..
  Fly   214 SPGQVHASLDNGSVAGSNLYGCSSASNPLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYT 278

Mouse    76 PP--YTAYPTPAQAYGIPPYSIKTEDSLNHSPSQSGFLSYGPSFSTAPAGQSPYTYPVHSTAG-- 136
            ||  |:.|.|        ||:..|  :...:..:.|          |.|..:.|..|.::.:|
  Fly   279 PPPFYSGYGT--------PYAAAT--AARQAKMEPG----------AAAAAAAYLTPSYAASGNN 323

Mouse   137 ---LYQGANGLTNTAGFGSVHQDYPSYPSFSQNQYPQYFSPSYNPPYV---PASS---------- 185
               ||.......|..|    .|||..|   ...||..|:||:...||.   |:||
  Fly   324 NSQLYSSPYAGYNNFG----QQDYGGY---YNEQYGNYYSPANYSPYAVSSPSSSASHGHGFHVA 381

Mouse   186 ----LCSSPLST--STYVLQ--EAPHN----VPSQ----------SSESLAGDYNTHNGPST-PA 227
                |..||..|  :|.|.|  .:||:    .||.          |:.:.|...|:..|.|. .|
  Fly   382 ASSNLSESPTDTHSTTPVHQTTHSPHSPLPISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTA 446

Mouse   228 KEGDTERPHRASDGKL-RGRSKRNSDPSP-------AGDNEI----ERVFVWDLDETIIIFHSLL 280
            ..|..........||. |.|.:|:..|||       .|::|.    |||||||||||:||||:||
  Fly   447 GSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTASDTGNSEAVKPPERVFVWDLDETLIIFHTLL 511

Mouse   281 TGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFS 345
            :|::|:||.||.::.:.|...||||:||:||||.|||::|:|||:|:|||||||||||||.|||:
  Fly   512 SGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFA 576

Mouse   346 TDGFH-STAPGA--SLCLGTGVHGGVDWMRKLAFRYRRVKEMYNTYRNNVGGLIGAPKRETWLQL 407
            ||||| :|.|||  :|||.|||.||||||||||||||::|::||:||.|||.|:|..|||.|||:
  Fly   577 TDGFHTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKREAWLQI 641

Mouse   408 RAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKT 472
            |:|:|..||.|.|.:||.|::|:.|.||||||||:|||.||||||||:|||.:|.|||||||.|.
  Fly   642 RSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKI 706

Mouse   473 GKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL 532
            |.|:|:|||:.|||||:.|:|||||.|||..||..|.||||||.|:|:.||..||::.:|
  Fly   707 GHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTALDMGFL 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eya2	NP_034295.1	PTZ00395	<54..>262	CDD:185594	68/303 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..258		19/78 (24%)
		HAD_Eya	261..532	CDD:319789	181/277 (65%)
eya	NP_723188.1	HAD_Eya	492..766	CDD:319789	181/273 (66%)