Protein Alignment MYO3B and MYO1

DIOPT Version :10

• Sequence 1: XP_011508956.1
• Gene: MYO3B / 140469
• HGNCID: 15576
• Length: 1386
• Species: Homo sapiens
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 1241
• Identity: 332/1241 - (26%)
• Similarity: 562/1241 - (45%)
• Gaps: 279/1241 - (22%)

Human   276 NHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTR 340
            |.|..|      |.:..:.|.||...:..:      :|.:::.|.       ||..:..:::
Yeast    35 NKFTGQ------EEQIGIVHPLDSTEVSNL------VQVRISDVF-------PVNPSTFDKV--- 77

Human   341 RPYHVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQF 405
                          :::..|..|:|.::::.|:|||...|||||.|..|:|:||:.||::||...
Yeast    78 --------------ENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDH 128

Human   406 SRLYHGV-KRASN-----------PPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLI 458
            ..|||.. .|.|.           ||||||.|:.||:.:::..|||.|:::||||:||||:...|
Yeast   129 INLYHNKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKI 193

Human   459 VQHLTFL--GKANN----------QTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTP 511
            :|:|..:  |..:|          ::...||||.|.::|:|||:.|..|:|||||||::::.|..
Yeast   194 LQYLASITSGSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNE 258

Human   512 TGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEE--KPPRYIADET 574
            .|::.||.|..|||||||::.|.::|:|:||||.:.:|| ...:|.:.||...  |..:.:::..
Yeast   259 HGMINGAHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGL-DDSELKNLRLKSRNVKDYKILSNSN 322

Human   575 GRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSE 639
            ..::..|...|:::....|:    .||||:..::..:::::|.||.||||||.       :|::|
Yeast   323 QDIIPGINDVENFKELLSAL----NIIGFSKDQIRWIFQVVAIILLIGNIEFV-------SDRAE 376

Human   640 VPNAEALQNAASVLC----ISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRL 700
               ..:.:|..|.:|    :..::.|.|:.........|.:.::....:|..:.:|:|:.||.||
Yeast   377 ---QASFKNDVSAICSNLGVDEKDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERL 438

Human   701 FSWIVNRINTLLQPDENICSAGGGMN-VGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVF 764
            |.:||:.||      :|:......:| :|:|||.|||.|:.|||||||||..||::|.:||.|:|
Yeast   439 FGYIVDMIN------KNLDHGSATLNYIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMF 497

Human   765 ALEQMEYQNEGIDAVPVEY-EDNRPLLDMFLQK--PLGLLALLDEESRFPQATDQT----LVDKF 822
            .|||.||..|.|....::| :|.:..:|:...|  |.|:|.|||||:..|::||::    |:..:
Yeast   498 VLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTW 562

Human   823 EDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSI 887
            :.|  ...|.|.: ::..|.::||||.|.|...|.|.||:|.|..:::.:|.:|:|.::.:||..
Yeast   563 DQN--SSKFKRSR-LKNGFILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQP 624

Human   888 PLTKTGNLAQTRARITVASSSLPPHFSAG-KAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDL 951
            ...|:.                    ||| :|.:...|| :....|:..|  |.:|..|...:.|
Yeast   625 EGEKSS--------------------SAGVEANISNQEV-KKSARTSTFK--TTSSRHREQQITL 666

Human   952 LSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFEEFVKRYY 1016
            |:::....|||||||.||:.::...|:|..:|.|||..|:||.:.:.|:||.:||.|:||.:||.
Yeast   667 LNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYR 731

Human  1017 YL-----AFTAHQTPL--ASKESCVAILEKSRLDHWV--LGKTKVFLK----------------- 1055
            .|     ..|...:.|  ::|::|..:|...:||..|  :|.||:|.|
Yeast   732 ILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLEKQKDVKLNN 796

Human  1056 ------------------YYHVEQLNLLLREVIGRVVVLQAYTK-----GWLG------------ 1085
                              .||:::|.  ...|||.  ..:.|.:     .|..
Yeast   797 IMIKLTATIRGYTVRKEITYHLQKLK--KTRVIGN--TFRLYNRLVKEDPWFNLFIRIKPLLTSS 857

Human  1086 --ARRYKRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAA 1148
              ..|.|:..|:..|    :::..:..::::||.:..|::..:...| ..|..||
Yeast   858 NDMTRTKKFNEQINK----LKNDLQEMESKKKFLEEKNQKTVNELEN-TQDLLNQ---------- 907

Human  1149 GTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNS------PAVTEKN--GSHSC 1205
                                    .:.:..:.||...|.:|||.:      ..|:||:  .....
Yeast   908 ------------------------EKENLRKNESLLNRVKTSSETLQKQFDDLVSEKDEISREKL 948

Human  1206 DIQTRAREEHPR-QEKQEWAIARGRICRAILGRHSQ--AQSSPKGCDIFAGHANKHSVSGT---- 1263
            ::.....|.|.: |..||....|......:..::::  .|.|...|||....:::..:..:
Yeast   949 EVAQNLEEAHQKIQGLQETIREREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIKESKLKL 1013

Human  1264 --------DLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRC-----QQPKMLSSP 1315
                    |:::|:..........||        .||..|..|..|..:.|     :...:::..
Yeast  1014 ENEIKRLKDVINSKEEEIKSFNDKLS--------SSEEDLDIKLVTLEKNCNIAMSRLQSLVTEN 1070

Human  1316 EDTMYYNQLNGTLEYQGSKRKPRKLGQIKVLDGEDEYYKSLSPVDCIPEENNSAHPSFFSSSSKG 1380
            .|....|:       ...|.|.....|:|  :.|.|..|....:|     |:....:.| |..:.
Yeast  1071 SDLRSKNE-------NFKKEKAALNNQLK--NKESELLKMKEKID-----NHKKELATF-SKQRD 1120

Human  1381 DSFAQH 1386
            |:.::|
Yeast  1121 DAVSEH 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO3B	XP_011508956.1	STKc_myosinIIIB_N	13..303	CDD:270808	7/26 (27%)
		MYSc_Myo3	366..1055	CDD:276830	253/736 (34%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	332/1241 (27%)
		Smc	1607..>1901	CDD:440809