DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO3B and MYO1

DIOPT Version :9

Sequence 1:	XP_011508956.1	Gene:	MYO3B / 140469	HGNCID:	15576	Length:	1386	Species:	Homo sapiens
Sequence 2:	NP_011888.1	Gene:	MYO1 / 856418	SGDID:	S000001065	Length:	1928	Species:	Saccharomyces cerevisiae

Alignment Length:	1241	Identity:	332/1241 - (26%)
Similarity:	562/1241 - (45%)	Gaps:	279/1241 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   276 NHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTR 340
            |.|..|      |.:..:.|.||...:..:      :|.:::.|.       ||..:..:::
Yeast    35 NKFTGQ------EEQIGIVHPLDSTEVSNL------VQVRISDVF-------PVNPSTFDKV--- 77

Human   341 RPYHVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQF 405
                          :::..|..|:|.::::.|:|||...|||||.|..|:|:||:.||::||...
Yeast    78 --------------ENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDH 128

Human   406 SRLYHGV-KRASN-----------PPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLI 458
            ..|||.. .|.|.           ||||||.|:.||:.:::..|||.|:::||||:||||:...|
Yeast   129 INLYHNKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKI 193

Human   459 VQHLTFL--GKANN----------QTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTP 511
            :|:|..:  |..:|          ::...||||.|.::|:|||:.|..|:|||||||::::.|..
Yeast   194 LQYLASITSGSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNE 258

Human   512 TGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEE--KPPRYIADET 574
            .|::.||.|..|||||||::.|.::|:|:||||.:.:|| ...:|.:.||...  |..:.:::..
Yeast   259 HGMINGAHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGL-DDSELKNLRLKSRNVKDYKILSNSN 322

Human   575 GRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSE 639
            ..::..|...|:::....|:    .||||:..::..:::::|.||.||||||.       :|::|
Yeast   323 QDIIPGINDVENFKELLSAL----NIIGFSKDQIRWIFQVVAIILLIGNIEFV-------SDRAE 376

Human   640 VPNAEALQNAASVLC----ISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRL 700
               ..:.:|..|.:|    :..::.|.|:.........|.:.::....:|..:.:|:|:.||.||
Yeast   377 ---QASFKNDVSAICSNLGVDEKDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERL 438

Human   701 FSWIVNRINTLLQPDENICSAGGGMN-VGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVF 764
            |.:||:.||      :|:......:| :|:|||.|||.|:.|||||||||..||::|.:||.|:|
Yeast   439 FGYIVDMIN------KNLDHGSATLNYIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMF 497

Human   765 ALEQMEYQNEGIDAVPVEY-EDNRPLLDMFLQK--PLGLLALLDEESRFPQATDQT----LVDKF 822
            .|||.||..|.|....::| :|.:..:|:...|  |.|:|.|||||:..|::||::    |:..:
Yeast   498 VLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTW 562

Human   823 EDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSI 887
            :.|  ...|.|.: ::..|.::||||.|.|...|.|.||:|.|..:::.:|.:|:|.::.:||..
Yeast   563 DQN--SSKFKRSR-LKNGFILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQP 624

Human   888 PLTKTGNLAQTRARITVASSSLPPHFSAG-KAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDL 951
            ...|:.                    ||| :|.:...|| :....|:..|  |.:|..|...:.|
Yeast   625 EGEKSS--------------------SAGVEANISNQEV-KKSARTSTFK--TTSSRHREQQITL 666

Human   952 LSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFEEFVKRYY 1016
            |:::....|||||||.||:.::...|:|..:|.|||..|:||.:.:.|:||.:||.|:||.:||.
Yeast   667 LNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYR 731

Human  1017 YL-----AFTAHQTPL--ASKESCVAILEKSRLDHWV--LGKTKVFLK----------------- 1055
            .|     ..|...:.|  ::|::|..:|...:||..|  :|.||:|.|
Yeast   732 ILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLEKQKDVKLNN 796

Human  1056 ------------------YYHVEQLNLLLREVIGRVVVLQAYTK-----GWLG------------ 1085
                              .||:::|.  ...|||.  ..:.|.:     .|..
Yeast   797 IMIKLTATIRGYTVRKEITYHLQKLK--KTRVIGN--TFRLYNRLVKEDPWFNLFIRIKPLLTSS 857

Human  1086 --ARRYKRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAA 1148
              ..|.|:..|:..|    :::..:..::::||.:..|::..:...| ..|..||
Yeast   858 NDMTRTKKFNEQINK----LKNDLQEMESKKKFLEEKNQKTVNELEN-TQDLLNQ---------- 907

Human  1149 GTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNS------PAVTEKN--GSHSC 1205
                                    .:.:..:.||...|.:|||.:      ..|:||:  .....
Yeast   908 ------------------------EKENLRKNESLLNRVKTSSETLQKQFDDLVSEKDEISREKL 948

Human  1206 DIQTRAREEHPR-QEKQEWAIARGRICRAILGRHSQ--AQSSPKGCDIFAGHANKHSVSGT---- 1263
            ::.....|.|.: |..||....|......:..::::  .|.|...|||....:::..:..:
Yeast   949 EVAQNLEEAHQKIQGLQETIREREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIKESKLKL 1013

Human  1264 --------DLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRC-----QQPKMLSSP 1315
                    |:::|:..........||        .||..|..|..|..:.|     :...:::..
Yeast  1014 ENEIKRLKDVINSKEEEIKSFNDKLS--------SSEEDLDIKLVTLEKNCNIAMSRLQSLVTEN 1070

Human  1316 EDTMYYNQLNGTLEYQGSKRKPRKLGQIKVLDGEDEYYKSLSPVDCIPEENNSAHPSFFSSSSKG 1380
            .|....|:       ...|.|.....|:|  :.|.|..|....:|     |:....:.| |..:.
Yeast  1071 SDLRSKNE-------NFKKEKAALNNQLK--NKESELLKMKEKID-----NHKKELATF-SKQRD 1120

Human  1381 DSFAQH 1386
            |:.::|
Yeast  1121 DAVSEH 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO3B	XP_011508956.1	STKc_myosinIIIB_N	13..303	CDD:270808	7/26 (27%)
		S_TKc	36..302	CDD:214567	7/25 (28%)
		MYSc	355..1062	CDD:214580	259/789 (33%)
		MYSc_Myo3	366..1055	CDD:276830	253/736 (34%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	332/1241 (27%)
MYO1	NP_011888.1	Smc	1534..>1890	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910