DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYO3B and MKK2

DIOPT Version :9

Sequence 1:	XP_011508956.1	Gene:	MYO3B / 140469	HGNCID:	15576	Length:	1386	Species:	Homo sapiens
Sequence 2:	NP_015185.1	Gene:	MKK2 / 855963	SGDID:	S000006061	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	294	Identity:	96/294 - (32%)
Similarity:	146/294 - (49%)	Gaps:	21/294 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    42 IGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNILQFLPNHPN--VVKFYGMFYKAD 104
            :|:|..|.|.|...|....:.|:|.::.::...|..:..:..|||..:..:  :|::||||....
Yeast   220 LGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQ 284

Human   105 HCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGN 169
               ...:::.:|...|.|:....|.||:.|.|:.|.:|..|....|.||.:||..::||||:|..
Yeast   285 ---SSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQ 346

Human   170 NILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGIT 234
            ||||..:|.:||.|||||.:..::...  |..||.|:||||.|     ....|...|||||||:|
Yeast   347 NILLNEKGEIKLCDFGVSGEAVNSLAM--TFTGTSFYMAPERI-----QGQPYSVTCDVWSLGLT 404

Human   235 AIELGDG------DPPLFDMHPVKTLFKIPRNPPPTLLHPE---KWCEEFNHFISQCLIKDFERR 290
            .:|:..|      |....::.|::.|..|....|.....||   .|.:.|..||..||.||...|
Yeast   405 LLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARER 469

Human   291 PSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQK 324
            ||...:|.||:|.|...|.:.:::.:.|..:.:|
Yeast   470 PSPRQMLKHPWIVGQMKKKVNMERFVKKCWEKEK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO3B	XP_011508956.1	STKc_myosinIIIB_N	13..303	CDD:270808	91/271 (34%)
		S_TKc	36..302	CDD:214567	91/270 (34%)
		MYSc	355..1062	CDD:214580
		MYSc_Myo3	366..1055	CDD:276830
MKK2	NP_015185.1	PKc_Pek1_like	212..499	CDD:270793	95/288 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910