DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYO3B and ppk11

DIOPT Version :9

Sequence 1:	XP_011508956.1	Gene:	MYO3B / 140469	HGNCID:	15576	Length:	1386	Species:	Homo sapiens
Sequence 2:	NP_594517.1	Gene:	ppk11 / 2541473	PomBaseID:	SPAC2C4.14c	Length:	312	Species:	Schizosaccharomyces pombe

Alignment Length:	267	Identity:	102/267 - (38%)
Similarity:	150/267 - (56%)	Gaps:	18/267 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    39 IETIGKGTYGKVYKVTNKRDGSLAAVKI--LDPVSDMDEEIEAEYNILQFLPNHPNVVKFYGMFY 101
            ::.||:|::|.|::..:.....:.|:|:  ||...|..|.:..|.|.|..| |..::.|:|..|.
pombe     9 LQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDL-NSVHITKYYASFV 72

Human   102 KADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDV 166
            .     |.:||:.:|.|:|||..:    ||:......|.:|:.::...|..|.:||....:|||:
pombe    73 D-----GFRLWITMEYCDGGSCLD----LLKLSGTFSERVIAEVMRQVLEALVYLHGQGKMHRDI 128

Human   167 KGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSL 231
            |..|||...:|.|||.|||||.||.|.|.:.:..|||||||||||:.     .:.|:.:.|:|||
pombe   129 KAANILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFWMAPEVVK-----QTGYNYKADIWSL 188

Human   232 GITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHL 296
            ||||.||..|:||...:||:|.|..||::.||: |...|:...|..|:|.||.|:.:.|.:..:|
pombe   189 GITAYELATGEPPYSGIHPMKVLLLIPKHSPPS-LERSKFSRAFCDFVSNCLKKNPKDRATAEYL 252

Human   297 LDHPFIK 303
            ..|.|||
pombe   253 SKHKFIK 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO3B	XP_011508956.1	STKc_myosinIIIB_N	13..303	CDD:270808	100/265 (38%)
		S_TKc	36..302	CDD:214567	99/264 (38%)
		MYSc	355..1062	CDD:214580
		MYSc_Myo3	366..1055	CDD:276830
ppk11	NP_594517.1	STKc_MST3_like	4..278	CDD:270786	102/267 (38%)
ppk11	NP_594517.1	S_TKc	6..258	CDD:214567	99/264 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910