DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tre1 and Aplnr

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_112639.1	Gene:	Aplnr / 83518	RGDID:	621645	Length:	377	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	75/353 - (21%)
Similarity:	146/353 - (41%)	Gaps:	74/353 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDQDMGMATGY-FQDADMQMDEPAAATQSIYPHSATLFAAISACVFVTIGVLGNLITLLALLKSP 64
            |:.|     || :..||.|.:    ...:.:..|..|..||...||: :|..||.:.|..:..|.
  Rat     1 MEDD-----GYNYYGADNQSE----CDYADWTPSGALIPAIYILVFL-LGTTGNGLVLWTVFWSS 55

  Fly    65 TIREHATTAFVISLSISDLLFCSFSLPLTAVRFFQE-SWTFGTTLCKIFPVIFYGNVAVSLLSMV 128
            ..:..:...|:.||:::||.|. .:|||.|...::| .|.|||..||:...:.:.|:..|:..:.
  Rat    56 REKRRSADIFIASLAVADLTFV-VTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLT 119

  Fly   129 GITLNRYILIACHSRYSQIYKPKFITLQLLFVWAVSFLLLLPPILGIWGEMGLDE---------- 183
            |::.:||:.|......:::.......:....:|.::.||.:|.:  ::....:.|
  Rat   120 GLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAVPVM--VFRSTDIPENSTKTQCYMD 182

  Fly   184 ----ATFSCTILKKEGRSIKKTLFVIGFLLPCLVIIVSYSCIYITVLHQKKKIRNHDNFQIAAAK 244
                ||.:.....:.|..:..|  .:||::|.::::..|..|..|:....:|.|
  Rat   183 YSMVATSNSEWAWEVGLGVSST--AVGFVVPFIIMLTCYFFIAQTIAGHFRKER----------- 234

  Fly   245 GSSSSGGGSYMTTTCTRKAREDNRLTVMMVTIFLCFLVCFLP-------LMLANVV------DDE 296
                           ....|:..||..::|.:.:.|.:|::|       .||.|::      |..
  Rat   235 ---------------IEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGNLLHWPCDFDSF 284

  Fly   297 RNTSYPWLHIIASVMAWASSVINPIIYA 324
            ....:|:    .:.:::.:|.:||.:||
  Rat   285 LMNVFPY----CTCISYVNSCLNPFLYA 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	59/298 (20%)
Aplnr	NP_112639.1	7tmA_Apelin_R	17..318	CDD:341340	68/328 (21%)
		TM helix 1	29..53	CDD:341340	8/24 (33%)
		TM helix 2	63..84	CDD:341340	9/21 (43%)
		TM helix 3	101..123	CDD:341340	4/21 (19%)
		TM helix 4	146..162	CDD:341340	3/15 (20%)
		TM helix 5	197..220	CDD:341340	5/24 (21%)
		TM helix 6	245..267	CDD:341340	4/21 (19%)
		TM helix 7	286..311	CDD:341340	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100