DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tre1 and gpr25

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	XP_001335309.4	Gene:	gpr25 / 795188	ZFINID:	ZDB-GENE-141216-12	Length:	377	Species:	Danio rerio

Alignment Length:	340	Identity:	79/340 - (23%)
Similarity:	137/340 - (40%)	Gaps:	71/340 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ADMQMDEPAAATQS--IY--------PHSATLFAAISACVFVTIGVLGNLITLLALLKSPTIREH 69
            ::...|.|..:|..  ||        |.|......:...:|:| |.||||..::.:.|.......
Zfish    18 SEYDYDYPINSTDENPIYTLPDAELLPMSNIYIPVLYIIMFLT-GSLGNLFVIVVIGKRRKKSGR 81

  Fly    70 ATTAFVISLSISDLLFCSFSLPLTAVRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNR 134
            ....||::|:::||:|. .:||:.|:....:.|.||..||||...|...|...::..:..::::|
Zfish    82 LVDTFVLNLALADLVFV-LTLPMWAISTRYDEWPFGEVLCKISSFIIAVNRFSNIFFLTCMSVDR 145

  Fly   135 YILIA--CHSRYSQIYKPKFITLQLLFVWAVSFLLLLPPILGIWGEMGLDEATFSCTILKKEGRS 197
            |:.:.  ..||:.:......||..:  ||.|||.|            |.....:...|.......
Zfish   146 YLAVVRLMDSRFLRSSNCAQITCGI--VWVVSFFL------------GSPSLAYRHLINNSVCSE 196

  Fly   198 IKKTLFVIG---------FLLPCLVIIVSYSCIYITVLHQKKKIRNHDNFQIAAAKGSSSSGGGS 253
            ..|:.||.|         ||||.|::.:.|..|.:.:   ::...|..|
Zfish   197 DSKSSFVQGMNLLTILLTFLLPVLILGLCYGSILVNL---RRHCHNPAN---------------- 242

  Fly   254 YMTTTCTRKAREDNRLTVMMVTIFL-------CFLVCFLPLMLANVVDDERNTSYPWLH---IIA 308
              |.|..|: |...::...:::.||       ||....:.|::.|  .|....:|..:|   :::
Zfish   243 --TRTDARR-RHSVKIVFAIISAFLISWLPFNCFKAIHVALLIIN--GDLNEDTYVVIHRGLMLS 302

  Fly   309 SVMAWASSVINPIIY 323
            ..:|:.:|.:||.||
Zfish   303 CCLAFLNSCVNPAIY 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	66/291 (23%)
gpr25	XP_001335309.4	7tmA_GPR25	48..328	CDD:320321	72/310 (23%)
		TM helix 1	49..75	CDD:320321	7/26 (27%)
		TM helix 2	83..108	CDD:320321	9/25 (36%)
		TM helix 3	120..150	CDD:320321	7/29 (24%)
		TM helix 4	163..184	CDD:320321	9/34 (26%)
		TM helix 5	203..232	CDD:320321	9/28 (32%)
		TM helix 6	247..277	CDD:320321	6/30 (20%)
		TM helix 7	296..321	CDD:320321	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100